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Oxolamine (hydrochloride)

CAT: 0804-HY-B1717ASize: 1 EachDry Ice: NoHazardous: No
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Description
Oxolamine hydrochloride (SKF-9976 hydrochloride) is an orally active antitussive. Oxolamine hydrochloride can inhibit CYP2B1/2. Oxolamine hydrochloride has anti-inflammatory effects on the respiratory organs of guinea pigs. Oxolamine hydrochloride increases the AUC of Warfarin and prolongs its terminal half-life. Oxolamine hydrochloride can be used in respiratory disease research[1][2][3][4].
CAS Number
1219-20-1
UNSPSC
12352005
Target
Cytochrome P450
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/oxolamine-hydrochloride.html
Smiles
CCN(CC)CCC1=NC(C2=CC=CC=C2)=NO1.Cl
Molecular Formula
C14H20ClN3O
Molecular Weight
281.78
References & Citations
[1]Kirilmaz L, et, al. Sustained-release dosage form of oxolamine citrate: preparation and release kinetics. J Microencapsul. Apr-Jun 1992;9 (2) :167-72.|[2]GIUDICI G, et, al. [On the anti-inflammatory action of oxolamine citrate]. Minerva Med. 1961 Oct 31;52:3752-5.|[3]Zhu X, et al. Gender difference in the pharmacokinetic interaction between oral warfarin and oxolamine in rats: inhibition of CYP2B1 by oxolamine in male rats. Biopharm Drug Dispos. 2007 Apr;28 (3) :125-33.|[4]Dahlgren S, et al. The effect of oxolamine citrate on experimentally produced inflammation in the respiratory organs. Acta Pharmacol Toxicol (Copenh) . 1966;24 (2) :286-96.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CYP2

Chemical Information

1,2,4-Oxadiazole-5-ethanamine, N,N-diethyl-3-phenyl-, hydrochloride (1:1)
CAS Number1219-20-1
PubChem CID76958540
IUPAC NameN,N-diethyl-2-(3-phenyl-1,2,4-oxadiazol-5-yl)ethanamine;hydrochloride
Molecular FormulaC14H20ClN3O
Molecular Weight281.78
Topological Polar Surface Area42.2
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count6
Heavy Atom Count19
Formal Charge0
Complexity227
SMILES
CCN(CC)CCC1=NC(=NO1)C2=CC=CC=C2.Cl
InChI
InChI=1S/C14H19N3O.ClH/c1-3-17(4-2)11-10-13-15-14(16-18-13)12-8-6-5-7-9-12;/h5-9H,3-4,10-11H2,1-2H3;1H
InChIKey
YHLIBHCNFDRYFW-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 1,2,4-Oxadiazole-5-ethanamine, N,N-diethyl-3-phenyl-, hydrochloride (1:1)
CAS: 1219-20-1
CID: 76958540
Formula: C14H20ClN3O
MW: 281.78
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight281.78
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count6
Exact Mass281.1294900
Monoisotopic Mass281.1294900
Topological Polar Surface Area42.2 Ų
Heavy Atom Count19
Formal Charge0
Complexity227
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

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