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Simmitecan (hydrochloride)

CAT: 0804-HY-107133-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-107133-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Simmitecan hydrochloride, a 9-substituted lipophilic Camptothecin derivative, is a potent topoisomerase I inhibitor. Simmitecan hydrochloride is an anticancer agent[1][2].
CAS Number
1247847-78-4
UNSPSC
12352005
Target
Cytochrome P450; Topoisomerase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/simmitecan-hydrochloride.html
Solubility
10 mM in DMSO
Smiles
[H]Cl.CC[C@]1(O)C(C=C2N3CC4=CC5=C(C=CC(OC(N6CCC(N7CCCCC7)CC6)=O)=C5CC=C)N=C42)=C(COC1=O)C3=O
Molecular Formula
C34H39ClN4O6
Molecular Weight
635.15
References & Citations
[1]Rini B, et al. A phase I/II study of lenalidomide in combination with sunitinib in patients with advanced or metastatic renal cell carcinoma. Ann Oncol. 2014 Sep;25 (9) :1794-1799. |[2]Hu ZY, et al. Pharmacokinetic evaluation of the anticancer prodrug simmitecan in different experimental animals. Acta Pharmacol Sin. 2013 Nov;34 (11) :1437-48.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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