PROTAC Bcl-xL degrader-2

• UNSPSC Description:

  PROTAC Bcl-xL degrader-2 is a potent Bcl-xL (Bcl-2 family member) degrader based on von Hippel-Lindau ligand, with an IC50 of 0.6 nM.

• Target Antigen:

  Bcl-2 Family; PROTACs

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;PROTAC

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/protac-bcl-xl-degrader-2.html

• Smiles:

  O=C(C1=C(CCCOC2=CC=C(C#CCOCCOCCOCCOCCOCCOCCC(N[C@H](C(N3[C@H](C(NCC4=CC=C(C5=C(C)N=CS5)C=C4)=O)C[C@@H](O)C3)=O)C(C)(C)C)=O)C=C2)SC(N6CC7=C(C=CC=C7C(NC8=NC9=CC=CC=C9S8)=O)CC6)=N1)O

• Molecular Weight:

  1329.60

• References & Citations:

  [1]Chun-Wa Chung, et al. Structural Insights into PROTAC-Mediated Degradation of Bcl-xL. ACS Chem Biol. 2020 Sep 18;15(9):2316-2323.

• Shipping Conditions:

  Room Temperature

• CAS Number:

  2920415-08-1