PF-05175157

CAT: 0804-HY-12942-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-12942-01Size:5 mg
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Description
PF-05175157 is broad spectrum acetyl-CoA carboxylase (ACC) inhibitor with IC50s of 27.0, 33.0, 23.5 and 50.4 nM for ACC1 (human), ACC2 (human), ACC1 (rat), ACC2 (rat), respectively.
CAS Number
[1301214-47-0]
UNSPSC
12352005
Hazard Statement
H315-H319-H335
Target
Acetyl-CoA Carboxylase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/PF-05175157.html
Purity
98.10
Solubility
DMSO : 30 mg/mL (ultrasonic; warming)
Smiles
O=C1CC2(CCN(C(C3=CC=C4C(NC(C)=N4)=C3)=O)CC2)CC5=C1N(C(C)C)N=C5
Molecular Formula
C23H27N5O2
Molecular Weight
405.49
Precautions
P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362-P403+P233-P405-P501
References & Citations
[1]David A, et al. Decreasing the Rate of Metabolic Ketone Reduction in the Discovery of a Clinical Acetyl-CoA Carboxylase Inhibitor for the Treatment of Diabetes. J Med Chem. 2014 Dec 26; 57 (24) : 10512–10526.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2

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