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SPD-502

CAT: 0804-HY-15074Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-15074Size:1 Each
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Description
SPD-502 is a novel glutamate antagonist with potential neuroprotective properties, particularly in brain ischemia. It selectively targets the AMPA receptor, showing high affinity (IC50 = 0.043 μM) and competitive inhibition of AMPA-induced effects in rat cortical membranes and cultured mouse cortical neurons. In vivo, SPD-502 effectively blocks AMPA-evoked spike activity in the hippocampus after intravenous administration, significantly increasing the seizure threshold in mice and demonstrating robust protection against ischemia-induced damage to hippocampal neurons in gerbils. These findings suggest SPD-502 may be promising for treating neurodegenerative conditions associated with glutamate excitotoxicity[1].
CAS Number
245063-59-6
Product Name Alternative
NS-1209
UNSPSC
12352005
Target
IGluR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/spd-502.html
Smiles
O=C(N1)/C(C2=C1C3=C(C(C4=CC=C(S(N(C)C)(=O)=O)C=C4)=C2)CCN(C)C3)=N\OC(C(O)=O)CCO
Molecular Formula
C24H28N4O7S
Molecular Weight
516.57
References & Citations
[1]SPD-502: A Water-Soluble and In Vivo Long-Lasting Ampa Antagonist with Neuroprotective Activity
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2

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