BMS-502

CAT: 0804-HY-149874-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-149874-01Size:5 mg
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Description
BMS-502 (Compound 22) is a potent dual inhibitor of diacylglycerol kinase (DGK) α and ζ with IC50 of 4.6 nM and 2.1 nM. BMS-502 enhanced T cell immune responses in mice. BMS-502 can be used in tumor immunity related research[1].
CAS Number
[2407854-18-4]
UNSPSC
12352005
Target
DGK
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Cancer
Assay Protocol
https://www.medchemexpress.com/bms-502.html
Purity
99.31
Solubility
DMSO : 100 mg/mL (ultrasonic; warming; heat to 80°C)
Smiles
N#CC1=NC2=C(N(C)C(C([N+]([O-])=O)=C2N3CCN(C(C4=CC=C(F)C=C4)C5=CC=C(F)C=C5)CC3)=O)C=C1
Molecular Formula
C27H22F2N6O3
Molecular Weight
516.50
References & Citations
[1]Chupak L, et al. Discovery of Potent, Dual-Inhibitors of Diacylglycerol Kinases Alpha and Zeta Guided by Phenotypic Optimization. ACS Med Chem Lett. 2023 Jun 12;14 (7) :929-935.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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