GRL093-22

• Description :

  GRL093-22 is a potent and selective G protein-coupled receptor kinase (GRK) inhibitor, with IC50s of 60 and 40 nM for GRK5 and GRK6, respectively. GRL093-22 has the potential for the research of heart failure and multiple myeloma[1].

• UNSPSC :

  12352005

• Target :

  G Protein-coupled Receptor Kinase (GRK)

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein

• Field of Research :

  Cancer; Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/grl093-22.html

• Purity :

  99.51

• Smiles :

  FC1=CC=C([C@H](NC(C2=CC=C(NC(/C3=C\C4=C(C)C(NC(C5=C(C)N=C6N5C=CC=C6)=O)=C(C)N4)=O)C3=C2)=O)C)C=C1

• Molecular Formula :

  C33H29FN6O3

• Molecular Weight :

  576.62

• References & Citations :

  [1]Ghosh AK, et, el. Design, synthesis, and X-ray structural studies of a series of highly potent, selective, and drug-like G protein-coupled receptor kinase 5 inhibitors. Eur J Med Chem. 2025 Jan 15:282:117024.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported