PI3Kδ-IN-22

• UNSPSC Description:

  PI3Kδ-IN-22 (Compound 26) is a selective inhibitor for PI3Kδ with pKi of 9.3. PI3Kδ-IN-22 inhibits PI3Kδ-AKT signaling pathway in THP-1 cells, with pIC50 of 9.4. PI3Kδ-IN-22 exhibits good pharmacokinetic characters in rats[1].

• Target Antigen:

  PI3K

• Type:

  Reference compound

• Related Pathways:

  PI3K/Akt/mTOR

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/pi3kδ-in-22.html

• Smiles:

  O=C1N(C(C)(C)C)N=CC([C@@H](N2N=C(C3=CC(F)=CC(O)=C3)C4=C2N=CN=C4N)C)=C1SCCN(CCO)CCO

• Molecular Weight:

  586.68

• References & Citations:

  [1]Bruno P, et al., Discovery and Optimization of Pyridazinones as PI3K Selective Inhibitors for Administration by Inhalation. J Med Chem. 2024 Jun 22.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported