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PI3Kδ-IN-22

CAT: 0804-HY-162647Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-162647Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PI3Kδ-IN-22 (Compound 26) is a selective inhibitor for PI3Kδ with pKi of 9.3. PI3Kδ-IN-22 inhibits PI3Kδ-AKT signaling pathway in THP-1 cells, with pIC50 of 9.4. PI3Kδ-IN-22 exhibits good pharmacokinetic characters in rats[1].
UNSPSC
12352005
Target
PI3K
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/pi3kδ-in-22.html
Smiles
O=C1N(C(C)(C)C)N=CC([C@@H](N2N=C(C3=CC(F)=CC(O)=C3)C4=C2N=CN=C4N)C)=C1SCCN(CCO)CCO
Molecular Formula
C27H35FN8O4S
Molecular Weight
586.68
References & Citations
[1]Bruno P, et al., Discovery and Optimization of Pyridazinones as PI3K Selective Inhibitors for Administration by Inhalation. J Med Chem. 2024 Jun 22.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PI3Kα; PI3Kβ; PI3Kγ; PI3Kδ

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