PI3Kδ-IN-22

• Description :

  PI3Kδ-IN-22 (Compound 26) is a selective inhibitor for PI3Kδ with pKi of 9.3. PI3Kδ-IN-22 inhibits PI3Kδ-AKT signaling pathway in THP-1 cells, with pIC50 of 9.4. PI3Kδ-IN-22 exhibits good pharmacokinetic characters in rats[1].

• UNSPSC :

  12352005

• Target :

  PI3K

• Type :

  Reference compound

• Related Pathways :

  PI3K/Akt/mTOR

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/pi3kδ-in-22.html

• Smiles :

  O=C1N(C(C)(C)C)N=CC([C@@H](N2N=C(C3=CC(F)=CC(O)=C3)C4=C2N=CN=C4N)C)=C1SCCN(CCO)CCO

• Molecular Formula :

  C27H35FN8O4S

• Molecular Weight :

  586.68

• References & Citations :

  [1]Bruno P, et al., Discovery and Optimization of Pyridazinones as PI3K Selective Inhibitors for Administration by Inhalation. J Med Chem. 2024 Jun 22.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  PI3Kα; PI3Kβ; PI3Kγ; PI3Kδ