PD-L1-IN-4

CAT: 0804-HY-162356Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-162356Size:1 Each

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Description

PD-L1-IN-4 (Compound X18) is an orally active PD-L1 inhibitor that exhibits remarkable inhibitory activity against the PD-1/PD-L1 interaction (IC50 = 1.3 nM) and enhances PD-L1 inhibitory effect on T cells (EC50 = 152.8 nM) . PD-L1-IN-4 can be used for the research of cancer[1].

CAS Number

2597056-86-3

UNSPSC

12352005

Target

PD-1/PD-L1

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pd-l1-in-4.html

Solubility

10 mM in DMSO

Smiles

FC1=C(C=CC=C1C2=CC(OCCCN3CCC(CC3)O)=CC=C2)COC4=CC(OCC5=CC6=NON=C6C=C5)=C(C=C4Cl)CN[C@@H](C(O)=O)CO

Molecular Formula

C38H40ClFN4O8

Molecular Weight

735.20

References & Citations

[1]Liu L, et al. Discovery of Novel PD-L1 Small-Molecular Inhibitors with Potent In Vivo Anti-tumor Immune Activity. J Med Chem. 2024 Mar 11.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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GTR19262088-01	PD-L1-IN-4
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RG-P022504-01	Pd-1/Pd-L1 Inhibitor Impurity 4
T209760-01	PD-1/PD-L1-IN-43
T208964-01	PD-1/PD-L1-IN-40
T207534-01	PD-1/PD-L1-IN-55
T200724-01	PD-1/PD-L1-IN-52
T200687-01	PD-1/PD-L1-IN-50
T64086-01	PD-1/PD-L1-IN-20

PD-L1-IN-4

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