PD-L1-IN-4

PD-L1-IN-4

• CAS Number: 2597056-86-3
• UNSPSC Description: PD-L1-IN-4 (Compound X18) is an orally active PD-L1 inhibitor that exhibits remarkable inhibitory activity against the PD-1/PD-L1 interaction (IC50 = 1.3 nM) and enhances PD-L1 inhibitory effect on T cells (EC50 = 152.8 nM). PD-L1-IN-4 can be used for the research of cancer[1].
• Target Antigen: PD-1/PD-L1
• Type: Reference compound
• Related Pathways: Immunology/Inflammation
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/pd-l1-in-4.html
• Solubility: 10 mM in DMSO
• Smiles: FC1=C(C=CC=C1C2=CC(OCCCN3CCC(CC3)O)=CC=C2)COC4=CC(OCC5=CC6=NON=C6C=C5)=C(C=C4Cl)CN[C@@H](C(O)=O)CO
• Molecular Weight: 735.20
• References & Citations: [1]Liu L, et al. Discovery of Novel PD-L1 Small-Molecular Inhibitors with Potent In Vivo Anti-tumor Immune Activity. J Med Chem. 2024 Mar 11.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported