Epsilon-V1-2

CAT: 0804-HY-P0154-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-P0154-01Size:5 mg
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Description
Epsilon-V1-2 (ε-V1-2), a PKCε-derived peptide, is a selective PKCε inhibitor. Epsilon-V1-2 inhibits the translocationof PKCε, but not α-, β-, and δPKC[1].
CAS Number
[182683-50-7]
Product Name Alternative
ε-V1-2; EAVSLKPT
UNSPSC
12352209
Target
PKC
Type
Peptides
Related Pathways
Epigenetics; TGF-beta/Smad
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/epsilon-v1-2.html
Purity
95.05
Solubility
H2O : ≥ 100 mg/mL
Smiles
O=C(N[C@@H](C)C(N[C@@H](C(C)C)C(N[C@@H](CO)C(N[C@@H](CC(C)C)C(N[C@@H](CCCCN)C(N1[C@@H](CCC1)C(N[C@@H]([C@H](O)C)C(O)=O)=O)=O)=O)=O)=O)=O)[C@H](CCC(O)=O)N
Molecular Formula
C37H65N9O13
Molecular Weight
843.96
References & Citations
[1]M Yedovitzky, et al. Translocation inhibitors define specificity of protein kinase C isoenzymes in pancreatic beta-cells. J Biol Chem. 1997 Jan 17;272 (3) :1417-20.|[2]Yuahn-Sieh Huang, et al. Mechanism of oleic acid-induced gap junctional disassembly in rat cardiomyocytes. J Mol Cell Cardiol. 2004 Sep;37 (3) :755-66.|[3]Tomoyoshi Koyanagi, et al. Pharmacological inhibition of epsilon PKC suppresses chronic inflammation in murine cardiac transplantation model. J Mol Cell Cardiol. 2007 Oct;43 (4) :517-22.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
PKCε

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