Epsilon-(gamma-glutamyl)-lysine

• UNSPSC Description:

  Epsilon-(gamma-glutamyl)-lysine is an N(6)-acyl-L-lysine derivative. The enzyme tissue transglutaminase (tTg) helps the formation of epsilon-(gamma-glutamyl)lysine bonds between ECM components in some disease, such as non-diabetic kidney, glaucoma filtration[1].

• Target Antigen:

  Endogenous Metabolite

• Type:

  Natural Products

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/epsilon-gamma-glutamyl-lysine.html

• Solubility:

  10 mM in DMSO

• Smiles:

  OC([C@@H](N)CCC(NCCCC[C@H](N)C(O)=O)=O)=O

• Molecular Weight:

  275.30

• References & Citations:

  [1]Siegfried G Priglinger, et al. Potential Role of Tissue Transglutaminase in Glaucoma Filtering Surgery. Invest Ophthalmol Vis Sci. 2006 Sep;47(9):3835-45.|[2]A M El Nahas, et al. Elevated Epsilon-(Gamma-Glutamyl)lysine in Human Diabetic Nephropathy Results From Increased Expression and Cellular Release of Tissue Transglutaminase.Nephron Clin Pract. 2004;97(3):c108-17.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  17105-15-6