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ANQ-11125 (TFA)

CAT: 0804-HY-P1233ASize: 1 EachDry Ice: NoHazardous: No
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Description
ANQ-11125 TFA is a potent and selective antagonist of motilin, with the pKd of 8.24. ANQ-11125 TFA blocks motilide-induced contractions in vitro in the rabbit[1][2].
UNSPSC
12352209
Target
Motilin Receptor
Type
Peptides
Related Pathways
GPCR/G Protein
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/anq-11125-tfa.html
Solubility
H2O
Smiles
OC(C(F)(F)F)=O.O=C(N[C@@H](C(C)C)C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC2=CC=CC=C2)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC3=CC=C(C=C3)O)C(NCC(N[C@@H](CCC(O)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC(C)C)C(N[C@@H](CCC(N)=O)C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC4=CC=CC=C4)N
Molecular Formula
C86H125N19O21.xC2HF3O2
Molecular Weight
1761.03 (free acid)
References & Citations
[1]Depoortere I, et, al. Antagonistic properties of [Phe3, Leu13]porcine motilin. Eur J Pharmacol. 1995 Nov 24; 286 (3) :241-7.|[2]Peeters TL, et, al. The motilin antagonist ANQ-11125 blocks motilide-induced contractions in vitro in the rabbit. Biochem Biophys Res Commun. 1994 Jan 28; 198 (2) : 411-6.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported

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