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MRE-269-d6

CAT: 0804-HY-79593S1-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-79593S1-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MRE-269-d6 is deuterium labeled MRE-269. MRE-269 is an active metabolite of selexipag, and acts as a selective IP receptor agonist.
CAS Number
1265295-56-4
Product Name Alternative
ACT-333679-d6
UNSPSC
12352005
Target
Isotope-Labeled Compounds; Prostaglandin Receptor
Type
Isotope-Labeled Compounds
Related Pathways
GPCR/G Protein; Others
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cardiovascular Disease; Endocrinology
Solubility
10 mM in DMSO
Smiles
O=C(O)COCCCCN(C1=NC(C2=CC=CC=C2)=C(C3=CC=CC=C3)N=C1)C(C([2H])([2H])[2H])C([2H])([2H])[2H]
Molecular Formula
C25H23D6N3O3
Molecular Weight
425.55
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Fuchikami C, et al. A comparison of vasodilation mode among selexipag (NS-304; [2-{4-[ (5,6-diphenylpyrazin-2-yl) (isopropyl) amino]butoxy}-N- (methylsulfonyl) acetamide]), its active metabolite MRE-269 and various prostacyclin receptor agonists in rat, porcin|[3]Kuwano K, et al. A long-acting and highly selective prostacyclin receptor agonist prodrug, 2-{4-[ (5,6-diphenylpyrazin-2-yl) (isopropyl) amino]butoxy}-N- (methylsulfonyl) acetamide (NS-304), ameliorates rat pulmonary hypertension with unique relaxant responses|[4]Orie NN, et al. Differential actions of the prostacyclin analogues treprostinil and iloprost and the selexipag metabolite, MRE-269 (ACT-333679) in rat small pulmonary arteries and veins. Prostaglandins Other Lipid Mediat. 2013 Oct;106:1-7
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Isoform
IP

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