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MRE-269

CAT: 0804-HY-79593-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-79593-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MRE-269 is an active metabolite of selexipag, and acts as a selective IP receptor agonist.
CAS Number
475085-57-5
Product Name Alternative
ACT-333679
UNSPSC
12352005
Hazard Statement
H302, H312, H332
Target
Prostaglandin Receptor
Type
Natural Products
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Cardiovascular Disease; Endocrinology
Assay Protocol
https://www.medchemexpress.com/MRE-269.html
Purity
99.14
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
OC(COCCCCN(C(C)C)C1=NC(C2=CC=CC=C2)=C(C3=CC=CC=C3)N=C1)=O
Molecular Formula
C25H29N3O3
Molecular Weight
419.52
Precautions
H302, H312, H332
References & Citations
[1]Fuchikami C, et al. A comparison of vasodilation mode among selexipag (NS-304; [2-{4-[ (5,6-diphenylpyrazin-2-yl) (isopropyl) amino]butoxy}-N- (methylsulfonyl) acetamide]), its active metabolite MRE-269 and various prostacyclin receptor agonists in rat, porcin|[2]Orie NN, et al. Differential actions of the prostacyclin analogues treprostinil and iloprost and the selexipag metabolite, MRE-269 (ACT-333679) in rat small pulmonary arteries and veins. Prostaglandins Other Lipid Mediat. 2013 Oct;106:1-7|[3]Kuwano K, et al. A long-acting and highly selective prostacyclin receptor agonist prodrug, 2-{4-[ (5,6-diphenylpyrazin-2-yl) (isopropyl) amino]butoxy}-N- (methylsulfonyl) acetamide (NS-304), ameliorates rat pulmonary hypertension with unique relaxant responses
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
IP

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