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Pergolide (mesylate) (Standard)

CAT: 0804-HY-13720ARSize: 1 EachDry Ice: NoHazardous: No
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Description
Pergolide (mesylate) (Standard) is the analytical standard of Pergolide (mesylate) . This product is intended for research and analytical applications. Pergolide mesylate (Pergolide methanesulfonate), an Ergoline derivative, is a potent and orally active dopamine D1 and D2 receptors agonist. Pergolide mesylate can be used for Parkinson's disease and hyperprolactinaemia research[1][2].
CAS Number
66104-23-2
Product Name Alternative
Pergolide methanesulfonate (Standard) ; LY127809 (Standard)
UNSPSC
12352005
Target
Dopamine Receptor; Reference Standards
Type
Reference Standards
Related Pathways
GPCR/G Protein; Neuronal Signaling; Others
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/pergolide-mesylate-standard.html
Smiles
[H][C@@]1(N(CCC)C[C@H](CSC)C[C@@]12[H])CC3=CNC4=CC=CC2=C43.CS(=O)(O)=O
Molecular Formula
C20H30N2O3S2
Molecular Weight
410.59
References & Citations
[1]S Franks, et al. Effectiveness of pergolide mesylate in long term treatment of hyperprolactinaemia. Br Med J (Clin Res Ed) . 1983 Apr 9;286 (6372) :1177-9.|[2]Daniela Uberti, et al. Pergolide protects SH-SY5Y cells against neurodegeneration induced by H (2) O (2) . Eur J Pharmacol. 2002 Jan 2;434 (1-2) :17-20.|[3]Alin Ciobica, et al. The effects of pergolide on memory and oxidative stress in a rat model of Parkinson's disease. J Physiol Biochem. 2012 Mar;68 (1) :59-69.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

Chemical Information

Pergolide Mesylate

Pergolide mesylate is a methanesulfonate salt obtained from pergolide by mixing eqimolar amount of pergolide and methanesulfonic acid. A dopamine D2 receptor agonist which also has D1 and D2 agonist properties, it is used in the management of Parkinson's disease, although it was withdrawn from the U.S. and Canadian markets in 2007 due to an increased risk of cardiac valve dysfunction. It has a role as a geroprotector, an antiparkinson drug and a dopamine agonist. It contains a pergolide(1+).

CAS Number66104-23-2
PubChem CID47812
IUPAC Name(6aR,9R,10aR)-9-(methylsulfanylmethyl)-7-propyl-6,6a,8,9,10,10a-hexahydro-4H-indolo[4,3-fg]quinoline;methanesulfonic acid
Molecular FormulaC20H30N2O3S2
Molecular Weight410.6
Topological Polar Surface Area107
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count4
Heavy Atom Count27
Formal Charge0
Complexity480
SMILES
CCCN1C[C@@H](C[C@H]2[C@H]1CC3=CNC4=CC=CC2=C34)CSC.CS(=O)(=O)O
InChI
InChI=1S/C19H26N2S.CH4O3S/c1-3-7-21-11-13(12-22-2)8-16-15-5-4-6-17-19(15)14(10-20-17)9-18(16)21;1-5(2,3)4/h4-6,10,13,16,18,20H,3,7-9,11-12H2,1-2H3;1H3,(H,2,3,4)/t13-,16-,18-;/m1./s1
InChIKey
UWCVGPLTGZWHGS-ZORIOUSZSA-N
Chemical Structure
2D Structure
2D structure of Pergolide Mesylate
CAS: 66104-23-2
CID: 47812
Formula: C20H30N2O3S2
MW: 410.6
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight410.6
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count4
Exact Mass410.16978517
Monoisotopic Mass410.16978517
Topological Polar Surface Area107 Ų
Heavy Atom Count27
Formal Charge0
Complexity480
Isotope Atom Count0
Defined Atom Stereocenter Count3
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

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