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Lomitapide (mesylate) (Standard)

CAT: 0804-HY-14668RSize: 1 EachDry Ice: NoHazardous: No
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Description
Lomitapide (mesylate) (Standard) is the analytical standard of Lomitapide (mesylate) . This product is intended for research and analytical applications. Lomitapide (AEGR-733; BMS-201038) mesylate is a highly effective MTP protein inhibitor with an in vitro IC50 value of 8nM.
CAS Number
202914-84-9
UNSPSC
12352100
Target
Microsomal Triglyceride Transfer Protein (MTP) ; Reference Standards
Related Pathways
Metabolic Enzyme/Protease; Others
Field of Research
Cardiovascular Disease
Smiles
O=C(C1(CCCCN2CCC(NC(C3=CC=CC=C3C4=CC=C(C(F)(F)F)C=C4)=O)CC2)C5=C(C6=C1C=CC=C6)C=CC=C5)NCC(F)(F)F.O=S(C)(O)=O
Molecular Formula
C40H41F6N3O5S
Molecular Weight
789.83
References & Citations
[1]Sulsky R, et al. 5-Carboxamido-1,3,2-dioxaphosphorinanes, potent inhibitors of MTP. Bioorg Med Chem Lett. 2004 Oct 18;14 (20) :5067-70.|[2]Lomitapide. Am J Cardiovasc Drugs. 2011 Oct 1;11 (5) :347-52.|[3]Perry CM. Lomitapide: a review of its use in adults with homozygous familial hypercholesterolemia. Am J Cardiovasc Drugs. 2013 Aug;13 (4) :285-96.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

Chemical Information

Lomitapide Mesylate

Lomitapide mesylate is a methanesulfonate (mesylate) salt prepared from equimolar amounts of lomitapide and methanesulfonic acid. Used as a complement to a low-fat diet and other lipid-lowering treatments in patients with homozygous familial hypercholesterolemia. It has a role as an anticholesteremic drug and a MTP inhibitor. It contains a lomitapide(1+).

CAS Number202914-84-9
PubChem CID11274333
IUPAC Namemethanesulfonic acid;N-(2,2,2-trifluoroethyl)-9-[4-[4-[[2-[4-(trifluoromethyl)phenyl]benzoyl]amino]piperidin-1-yl]butyl]fluorene-9-carboxamide
Molecular FormulaC40H41F6N3O5S
Molecular Weight789.8
Topological Polar Surface Area124
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count12
Rotatable Bond Count10
Heavy Atom Count55
Formal Charge0
Complexity1200
SMILES
CS(=O)(=O)O.C1CN(CCC1NC(=O)C2=CC=CC=C2C3=CC=C(C=C3)C(F)(F)F)CCCCC4(C5=CC=CC=C5C6=CC=CC=C64)C(=O)NCC(F)(F)F
InChI
InChI=1S/C39H37F6N3O2.CH4O3S/c40-38(41,42)25-46-36(50)37(33-13-5-3-10-30(33)31-11-4-6-14-34(31)37)21-7-8-22-48-23-19-28(20-24-48)47-35(49)32-12-2-1-9-29(32)26-15-17-27(18-16-26)39(43,44)45;1-5(2,3)4/h1-6,9-18,28H,7-8,19-25H2,(H,46,50)(H,47,49);1H3,(H,2,3,4)
InChIKey
QKVKOFVWUHNEBX-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Lomitapide Mesylate
CAS: 202914-84-9
CID: 11274333
Formula: C40H41F6N3O5S
MW: 789.8
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight789.8
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count12
Rotatable Bond Count10
Exact Mass789.26711156
Monoisotopic Mass789.26711156
Topological Polar Surface Area124 Ų
Heavy Atom Count55
Formal Charge0
Complexity1200
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
M13157-01Lomitapide Mesylate
A16600-50Lomitapide mesylate 50mg
A16600-5Lomitapide mesylate 5mg
A16600-100Lomitapide mesylate 100mg
A16600-200Lomitapide mesylate 200mg
A16600-25Lomitapide mesylate 25mg
A16600-10Lomitapide mesylate 10mg
A16600-2Lomitapide mesylate 2mg
A16600-10mM-DLomitapide mesylate 10mM * 1mL in DMSO

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