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Bromocriptine (mesylate) (Standard)

CAT: 0804-HY-12705AR-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-12705AR-01Size:5 mg
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Description
Bromocriptine (mesylate) (Standard) is the analytical standard of Bromocriptine (mesylate) . This product is intended for research and analytical applications. Bromocriptine mesylate is a potent dopamine D2/D3 receptor agonist, which binds D2 dopamine receptor with pKi of 8.05±0.2.
CAS Number
22260-51-1
Product Name Alternative
CB-154 (Standard)
UNSPSC
12352005
Target
Autophagy; Dopamine Receptor; Reference Standards
Type
Reference compound
Related Pathways
Autophagy; GPCR/G Protein; Neuronal Signaling; Others
Field of Research
Neurological Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/bromocriptine-mesylate-standard.html
Smiles
[H][C@@]12CC3=C(Br)NC4=CC=CC(C1=C[C@@H](C(N[C@@]5(C(C)C)C(N6[C@@H](CC(C)C)C(N7CCC[C@]7([C@]6(O)O5)[H])=O)=O)=O)CN2C)=C43.OS(=O)(C)=O
Molecular Formula
C33H44BrN5O8S
Molecular Weight
750.70
References & Citations
[1]Gardner B, et al. Agonist action at D2 (long) dopamine receptors: ligand binding and functional assays. Br J Pharmacol. 1998 Jul;124 (5) :978-84.|[2]Renodon A, et al. Bromocriptine is a strong inhibitor of brain nitric oxide synthase: possible consequences for the origin of its therapeutic effects.FEBS Lett. 1997 Apr 7;406 (1-2) :33-6.|[3]Wynalda MA, et al. Assessment of potential interactions between dopamine receptor agonists and various human cytochrome P450 enzymes using a simple in vitro inhibition screen. Drug Metab Dispos. 1997 Oct;25 (10) :1211-4.|[4]Rana DG, et al. Dopamine mediated antidepressant effect of Mucuna pruriens seeds in various experimental models of depression. Ayu. 2014 Jan;35 (1) :90-7.|[5]Dieb W, et al. Nigrostriatal dopaminergic depletion increases static orofacial allodynia. J Headache Pain. 2016;17:11.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

Chemical Information

Bromocriptine Mesylate

Bromocriptine methanesulfonate is a methanesulfonate salt. It has a role as an antiparkinson drug. It contains a bromocriptine.

CAS Number22260-51-1
PubChem CID31100
IUPAC Name(6aR,9R)-5-bromo-N-[(1S,2S,4R,7S)-2-hydroxy-7-(2-methylpropyl)-5,8-dioxo-4-propan-2-yl-3-oxa-6,9-diazatricyclo[7.3.0.02,6]dodecan-4-yl]-7-methyl-6,6a,8,9-tetrahydro-4H-indolo[4,3-fg]quinoline-9-carboxamide;methanesulfonic acid
Molecular FormulaC33H44BrN5O8S
Molecular Weight750.7
Topological Polar Surface Area181
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count9
Rotatable Bond Count5
Heavy Atom Count48
Formal Charge0
Complexity1320
SMILES
CC(C)C[C@H]1C(=O)N2CCC[C@H]2[C@]3(N1C(=O)[C@](O3)(C(C)C)NC(=O)[C@H]4CN([C@@H]5CC6=C(NC7=CC=CC(=C67)C5=C4)Br)C)O.CS(=O)(=O)O
InChI
InChI=1S/C32H40BrN5O5.CH4O3S/c1-16(2)12-24-29(40)37-11-7-10-25(37)32(42)38(24)30(41)31(43-32,17(3)4)35-28(39)18-13-20-19-8-6-9-22-26(19)21(27(33)34-22)14-23(20)36(5)15-18;1-5(2,3)4/h6,8-9,13,16-18,23-25,34,42H,7,10-12,14-15H2,1-5H3,(H,35,39);1H3,(H,2,3,4)/t18-,23-,24+,25+,31-,32+;/m1./s1
InChIKey
NOJMTMIRQRDZMT-GSPXQYRGSA-N
Chemical Structure
2D Structure
2D structure of Bromocriptine Mesylate
CAS: 22260-51-1
CID: 31100
Formula: C33H44BrN5O8S
MW: 750.7
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight750.7
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count9
Rotatable Bond Count5
Exact Mass749.20940
Monoisotopic Mass749.20940
Topological Polar Surface Area181 Ų
Heavy Atom Count48
Formal Charge0
Complexity1320
Isotope Atom Count0
Defined Atom Stereocenter Count6
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

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Alternative Products

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0427/50Bromocriptine mesylate
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BB164266Bromocriptine mesylate - Bio-X TM
RM-B031800-01Bromocriptine Mesylate discontinued see RM-B031880
TBI1096-100MGBromocriptine mesylate, Dopamine D2/D3 agonist
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