AG 879

• Background:

  A879 is a selective inhibitor of the tyrosine kinase activity of nerve growth factor (NGF) TrkA. It also inhibits ErbB2 and VEGFR-2.

• Description:

  NGFR kinase inhibitor

• Product Name Alternative:

  Tyrphostin AG 879, α-Cyano- (3,5-di-t-butyl-4-hydroxy) thiocinnamide

• UNSPSC:

  41116105

• Type:

  Inhibitor

• Source:

  Synthetic

• Field of Research:

  Cell Signaling | Cancer | Apoptosis | Cancer Growth Inhibitors | Tyrosine Kinase Inhibitors

• Purity:

  ≥99% (TLC)

• Weight:

  0.025

• Format:

  Yellow solid

• Solubility:

  Soluble in 100% ethanol (25 mg/ml) or DMSO (25 mg/ml)

• Molecular Formula:

  C18H24N2OS

• Molecular Weight:

  316.5

• Precautions:

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations:

  1. He H., et al. (2004) Cancer Biol. Therapy. 3(1): 96–101. 2. Ohmichi M., et al. (1993) Biochem. 32(17): 4650–4658.

• CAS Number:

  148741-30-4