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AG 1478

CAT: 0400-SIH-425-25MGSize: 25 mgDry Ice: NoHazardous: No
CAT#:0400-SIH-425-25MGSize:25 mg
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Background
AG 1478 is a potent and selective inhibitor of EGFR. It does so by reducing EGF-stimulated DNA synthesis (seen in rat fibroblasts) and blocking EGF-dependent src-family kinase activation and p21/Cip 1/WAF1 induction (seen in A431 cells). AG 1478 is cell-permeable and active in vivo.
Description
EGFR kinase inhibitor
CAS Number
153436-53-4
Product Name Alternative
N- (3-Chlorophenyl) -6,7-dimethoxy-4-quinazolinamine, 4- (3-Chloroanilino) -6,7-dimethoxyquinazoline
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Cell Signaling | Cancer | Apoptosis | Cancer Growth Inhibitors | Tyrosine Kinase Inhibitors
Purity
≥98% (HPLC)
Weight
0.025
Format
White to light yellow solid
Solubility
Soluble in DMSO (10 mg/ml)
Molecular Formula
C16H14ClN3O2
Molecular Weight
315.8
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Osherov N., & Levitzki A. (1994) Euro J. Biochem. 225(3): 1047–1053. 2. Miyazaki Y., et al. (1996) Biochem. Biophys. Research Comm. 226(2): 542–546. 3. Fan Z., et al. (1995) J Cell Biol. 131(1): 235–242.

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