AG 1478

• Background:

  AG 1478 is a potent and selective inhibitor of EGFR. It does so by reducing EGF-stimulated DNA synthesis (seen in rat fibroblasts) and blocking EGF-dependent src-family kinase activation and p21/Cip 1/WAF1 induction (seen in A431 cells). AG 1478 is cell-permeable and active in vivo.

• Description:

  EGFR kinase inhibitor

• Product Name Alternative:

  N- (3-Chlorophenyl) -6,7-dimethoxy-4-quinazolinamine, 4- (3-Chloroanilino) -6,7-dimethoxyquinazoline

• UNSPSC:

  41116105

• Type:

  Inhibitor

• Source:

  Synthetic

• Field of Research:

  Cell Signaling | Cancer | Apoptosis | Cancer Growth Inhibitors | Tyrosine Kinase Inhibitors

• Purity:

  ≥98% (HPLC)

• Weight:

  0.025

• Format:

  White to light yellow solid

• Solubility:

  Soluble in DMSO (10 mg/ml)

• Molecular Formula:

  C16H14ClN3O2

• Molecular Weight:

  315.8

• Precautions:

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations:

  1. Osherov N., & Levitzki A. (1994) Euro J. Biochem. 225(3): 1047–1053. 2. Miyazaki Y., et al. (1996) Biochem. Biophys. Research Comm. 226(2): 542–546. 3. Fan Z., et al. (1995) J Cell Biol. 131(1): 235–242.

• CAS Number:

  153436-53-4