AG 494

• Background:

  AG 494 is a potent inhibitor of epidermal growth factor receptor (EGFR) kinase. It specifically inhibits EGF receptor autophosphorylation and EGF-dependent cell growth.

• Description:

  EGFR kinase inhibitor

• Product Name Alternative:

  AG-494, (E) -2-Cyano-3- (3,4-dihydroxyphenyl) -N-phenyl-2-propenamide

• UNSPSC:

  41116105

• Type:

  Inhibitor

• Source:

  Synthetic

• Field of Research:

  Cell Signaling | Cancer | Apoptosis | Cancer Growth Inhibitors | Tyrosine Kinase Inhibitors

• Purity:

  ≥98% (TLC)

• Weight:

  0.01

• Format:

  Yellow solid

• Solubility:

  Soluble in DMSO (25 mg/ml) or 100% ethanol (25 mg/ml)

• Molecular Formula:

  C16H12N2O3

• Molecular Weight:

  280.3

• Precautions:

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations:

  1. Ben-Bassat H., et al. (1999).J. Pharm. Exp. Ther. 290(3): 1442–1457. 2. Kleinberger-Doron N., Shelah N., Capone R., Gazit A., & Levitzki A. (1998) Exp. Cell . Res. 241(2): 340–351.

• CAS Number:

  133550-35-3