AG 494

• Background :

  AG 494 is a potent inhibitor of epidermal growth factor receptor (EGFR) kinase. It specifically inhibits EGF receptor autophosphorylation and EGF-dependent cell growth.

• Description :

  EGFR kinase inhibitor

• Product Name Alternative :

  AG-494, (E) -2-Cyano-3- (3,4-dihydroxyphenyl) -N-phenyl-2-propenamide

• UNSPSC :

  41116105

• Type :

  Inhibitor

• Source :

  Synthetic

• Field of Research :

  Cell Signaling | Cancer | Apoptosis | Cancer Growth Inhibitors | Tyrosine Kinase Inhibitors

• Purity :

  ≥98% (TLC)

• Weight :

  0.05

• Format :

  Yellow solid

• Solubility :

  Soluble in DMSO (25 mg/ml) or 100% ethanol (25 mg/ml)

• Molecular Formula :

  C16H12N2O3

• Molecular Weight :

  280.3

• Precautions :

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations :

  1. Ben-Bassat H., et al. (1999).J. Pharm. Exp. Ther. 290(3): 1442–1457. 2. Kleinberger-Doron N., Shelah N., Capone R., Gazit A., & Levitzki A. (1998) Exp. Cell . Res. 241(2): 340–351.

• CAS Number :

  133550-35-3