YM-01

• Background:

  YM-01 is an allosteric Hsp70 inhibitor. It binds with in Hsp70's nucleotide binding domain, adjacent to ATP/ADP binding pocket. It inhibits J-stimulated ATP turnover rate. It blocks Hsc70-bag1 interaction both in vitro and in vivo and enhances binding of Hsp70 to misfolded proteins. It reduces tau levels in tau-overexpressed HeLa cells, endogenous tau in neuroblastoma cells, and endogenous tau in primary neuron from rTg4510 mice, with EC50's of low micromolar. It recovers long-term potentiation deficits in brain slices from rTg4510 mice. It also has anti-cancer activity, with an EC50 value of low micromolar against several cancer cell lines. It destabilizes oncoproteins in cells, including Akt and Raf-1. Looking for more information on HSP70? Visit our new HSP70 Scientific Resource Guide at http://www.HSP70.com.

• Description:

  Hsp70 Inhibitor

• Product Name Alternative:

  2- ((Z) - ((E) -3-ethyl-5- (3-methylbenzo[d]thiazol-2 (3H) -ylidene) -4-oxothiazolidin-2-ylidene) methyl) -1-methylpyridin-1-ium chloride; YM-1

• UNSPSC:

  41116105

• Type:

  Inhibitor

• Source:

  Synthetic

• Field of Research:

  Cancer | Heat Shock | Apoptosis | Cell Signaling | Neuroscience | Neurodegeneration | Alzheimer's Disease

• Purity:

  >98% (HPLC)

• Weight:

  0.025

• Format:

  Orange red solid

• Solubility:

  Soluble in warm water (2 mg/ml)

• Molecular Formula:

  C20H20ClN3OS2

• Molecular Weight:

  417.97

• Precautions:

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations:

  1. Wang et al., 2013 Nature Chem. Biol. 9: 112-118. 2. Abisambra et al., 2013 Biol. Psychiatry, 74: 367-374. 3. Koren et al. PLoS One 7:e35566. 4. Morishima et al. 2011 Biochemistry. 50: 7146. 5. Davis et al. 2012 J. Immunol. 189: 4488.

• CAS Number:

  409086-68-6