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YM-01

CAT: 400-SIH-121-10MGSize: 10 mgDry Ice: NoHazardous: No
10 mgSelected
PRICE
AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
YM-01 is an allosteric Hsp70 inhibitor. It binds with in Hsp70's nucleotide binding domain, adjacent to ATP/ADP binding pocket. It inhibits J-stimulated ATP turnover rate. It blocks Hsc70-bag1 interaction both in vitro and in vivo and enhances binding of Hsp70 to misfolded proteins. It reduces tau levels in tau-overexpressed HeLa cells, endogenous tau in neuroblastoma cells, and endogenous tau in primary neuron from rTg4510 mice, with EC50's of low micromolar. It recovers long-term potentiation deficits in brain slices from rTg4510 mice. It also has anti-cancer activity, with an EC50 value of low micromolar against several cancer cell lines. It destabilizes oncoproteins in cells, including Akt and Raf-1. Looking for more information on HSP70? Visit our new HSP70 Scientific Resource Guide at http://www.HSP70.com.
Description
Hsp70 Inhibitor
CAS Number
409086-68-6
Product Name Alternative
2- ((Z) - ((E) -3-ethyl-5- (3-methylbenzo[d]thiazol-2 (3H) -ylidene) -4-oxothiazolidin-2-ylidene) methyl) -1-methylpyridin-1-ium chloride; YM-1
UNSPSC
41116105
Type
Inhibitor
Source
Synthetic
Field of Research
Cancer | Heat Shock | Apoptosis | Cell Signaling | Neuroscience | Neurodegeneration | Alzheimer's Disease
Purity
>98% (HPLC)
Weight
0.01
Format
Orange red solid
Solubility
Soluble in warm water (2 mg/ml)
Molecular Formula
C20H20ClN3OS2
Molecular Weight
417.97
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Wang et al., 2013 Nature Chem. Biol. 9: 112-118. 2. Abisambra et al., 2013 Biol. Psychiatry, 74: 367-374. 3. Koren et al. PLoS One 7:e35566. 4. Morishima et al. 2011 Biochemistry. 50: 7146. 5. Davis et al. 2012 J. Immunol. 189: 4488.

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