YM-58483

• Background :

  YM-58483 is a calcium release-activated calcium channel blocker. It inhibits antigen-induced histamine release via modulation of mast cell responses. It also is a potent T-cell antiproliferative agent.

• Description :

  CRAC channel blocker

• Product Name Alternative :

  N-[4-[3,5-Bis (trifluoromethyl) -1H-pyrazol-1-yl]phenyl]-4-methyl-1,2,3-thiadiazole-5-carboxamide; BTP2

• UNSPSC :

  41116105

• Type :

  Blocker

• Source :

  Synthetic

• Field of Research :

  Neuroscience | Neurotransmission | Ion Channels | Calcium Channels

• Purity :

  >98% (TLC) ; NMR (Conforms)

• Weight :

  0.005

• Format :

  Off-white powder

• Solubility :

  May be dissolved in DMSO (40 mg/ml)

• Molecular Formula :

  C15H9F6N5OS

• Molecular Weight :

  421.3

• Precautions :

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations :

  1. Zitt. C., et al. (2004) J. Biol. Chem. 279(13): 12427-12437. 2. Law M., et al. (2001) Int. J. Biochem. Cell Biol. 43:1228-1239. 3. K Ohga et al. (2008) Int. Immunopharmacol. 8:1787-1792.

• CAS Number :

  223499-30-7