YM-58483

• Background:

  YM-58483 is a calcium release-activated calcium channel blocker. It inhibits antigen-induced histamine release via modulation of mast cell responses. It also is a potent T-cell antiproliferative agent.

• Description:

  CRAC channel blocker

• Product Name Alternative:

  N-[4-[3,5-Bis (trifluoromethyl) -1H-pyrazol-1-yl]phenyl]-4-methyl-1,2,3-thiadiazole-5-carboxamide; BTP2

• UNSPSC:

  41116105

• Type:

  Blocker

• Source:

  Synthetic

• Field of Research:

  Neuroscience | Neurotransmission | Ion Channels | Calcium Channels

• Purity:

  >98% (TLC) ; NMR (Conforms)

• Weight:

  0.005

• Format:

  Off-white powder

• Solubility:

  May be dissolved in DMSO (40 mg/ml)

• Molecular Formula:

  C15H9F6N5OS

• Molecular Weight:

  421.3

• Precautions:

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations:

  1. Zitt. C., et al. (2004) J. Biol. Chem. 279(13): 12427-12437. 2. Law M., et al. (2001) Int. J. Biochem. Cell Biol. 43:1228-1239. 3. K Ohga et al. (2008) Int. Immunopharmacol. 8:1787-1792.

• CAS Number:

  223499-30-7