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MDM2 Antibody

CAT: 0400-SPC-778SSize: 12 µgDry Ice: NoHazardous: No
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CAT#:0400-SPC-778SSize:12 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
MDM2 (Mouse Double Minute 2 homolog) is an E3 ubiquitin ligase that negatively regulates the tumor suppressor p53, controlling its stability and transcriptional activity. In the nervous system, MDM2-p53 signaling is crucial for balancing neuronal survival and apoptosis. Overactivation of p53, due to MDM2 dysfunction, can lead to excessive neuronal loss—a feature observed in neurodegenerative diseases such as Parkinson’s and ALS. MDM2 also influences synaptic plasticity and neurogenesis, suggesting broader roles in cognitive function and brain repair. Targeting the MDM2-p53 axis offers a potential neuroprotective strategy by modulating stress responses and preventing p53-mediated neurotoxicity in degenerative conditions.
Description
Rabbit Anti-Human MDM2 Polyclonal
CAS Number
9007-83-4
Specifications
Detects ~50 kDa. ~50 kDa band is isoform 2 or 3.
Product Name Alternative
MDM2, Double minute 2 protein, Hdm2, MTBP, Mouse Double Minute 2, HDMX, ACTFS, p53 Binding Protein Mdm2, Ubiquitin protein ligase E3 Mdm2, Mdm2 p53 E3 ubiquitin protein ligase homolog, MDM2BP, p53-binding protein Mdm2, Oncoprotein Mdm2, Hdm 2, E3 ubiquitin-protein ligase Mdm2, MDM 2, EC:6.3.2.-, MDM2_HUMAN, MDM2 oncogene E3 ubiquitin protein ligase, Murine Double Minute Chromosome 2, Mdm2 transformed 3T3 cell double minute 2 p53 binding protein (mouse) binding protein 104kDa
UNSPSC
12352203
UN Code
Non-hazardous
Hazard Statement
Non-hazardous
Gene ID
4193
Swiss Prot
Q00987
Accession Number
NP_001138811.1
Cellular Locus
Nucleus | Nucleoplasm | Cytoplasm | Nucleus | Nucleolus
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide from the mid-protein of Human MDM2 (aa. 100-200)
Target
MDM2
Clonality
Polyclonal
Conjugation
Unconjugated
Tissue Specificity
Ubiquitous. Isoform Mdm2-A, isoform Mdm2-B, isoform Mdm2-C, isoform Mdm2-D, isoform Mdm2-E, isoform Mdm2-F and isoform Mdm2-G are observed in a range of cancers but absent in normal tissues.
Type
Polyclonal
Applications
WB | IHC
Validated Applications
WB, IHC
Field of Research
Cancer | Cell Cycle | p53 Pathway | Cell Signaling | Epigenetics and Nuclear Signaling | Cancer | Tumor Biomarkers | Oncoproteins
Purification
Peptide Affinity Purified
Detection Range
[object Object]
Concentration
1 mg/ml
Dilution
WB (1:1000) ; IHC (1:50) ; optimal dilutions for assays should be determined by the user.
Weight
0.1
Buffer
PBS pH 7.4, 50% glycerol, 0.09% sodium azide *Storage buffer changes when conjugated
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Shipping Conditions
Blue Ice or 4ºC
Storage Conditions
-20ºC
Specificity
Detects ~50 kDa. ~50 kDa band is isoform 2 or 3.
Species
Human | Mouse | Rat
Location
Nucleus | Nucleoplasm | Cytoplasm | Nucleus | Nucleolus
Immunogen Species
Human

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