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KRAS Antibody

CAT: 0400-SPC-777SSize: 12 µgDry Ice: NoHazardous: No
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CAT#:0400-SPC-777SSize:12 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
KRAS, a well-characterized oncogene encoding a small GTPase, is emerging as a critical player in neurodegenerative disease research. Traditionally studied in cancer biology, KRAS regulates key cellular processes such as proliferation, differentiation, and survival through the MAPK/ERK and PI3K/AKT pathways. Recent studies suggest that dysregulation of KRAS signaling may contribute to neuronal vulnerability, synaptic dysfunction, and neuroinflammation—hallmarks of disorders like Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis (ALS) . In the central nervous system, KRAS is expressed in neurons and glial cells, where it modulates neurodevelopmental signaling and cellular stress responses. Aberrant KRAS activity has been linked to impaired autophagy, mitochondrial dysfunction, and altered neurotrophic signaling, all of which are implicated in progressive neurodegeneration. Moreover, KRAS-mediated pathways intersect with tau phosphorylation and amyloid precursor protein processing, positioning KRAS as a potential upstream regulator of pathogenic cascades. Understanding KRAS function in neural contexts opens new avenues for therapeutic intervention. Targeting KRAS or its downstream effectors may offer neuroprotective strategies, particularly in early-stage disease. As neuroscience increasingly intersects with molecular oncology, KRAS represents a promising biomarker and mechanistic bridge between cancer biology and neurodegeneration.
Description
Rabbit Anti-Human KRAS Polyclonal
CAS Number
9007-83-4
Specifications
Detects ~29 kDa. Band is higher than the predicted molecular weight due to post translational modifications.
Product Name Alternative
KRAS, KRAS1, KRAS2, K-Ras 2, K RAS2A, K RAS2B, K RAS4A, K RAS4B, Ki-Ras, c-Ki-ras, c-K-ras, cK Ras, cK-ras, RASK2, RASK_HUMAN, NS3, NS, p21ras, K RAS p21 protein, GTPase KRas, Transforming protein p21, Oncogene KRAS2, Kirsten rat sarcoma 2 viral (v Ki ras2) oncogene homolog, v Ki ras2 Kirsten rat sarcoma viral oncogene homolog, Cellular c Ki ras2 proto oncogene, PR310 cK ras oncogene, KIRSTEN MURINE SARCOMA VIRUS 2
UNSPSC
12352203
UN Code
Non-hazardous
Hazard Statement
Non-hazardous
Gene ID
3845
Swiss Prot
P01116
Accession Number
NP_004976.2
Cellular Locus
Cell Membrane | Lipid-Anchor | Cytoplasmic Side | Cytoplasm | Cytosol
Host
Rabbit
Species Reactivity
Rat
Immunogen
Synthetic peptide from the C-terminal of Human KRAS (aa. 100-189)
Target
KRAS
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Polyclonal
Applications
WB
Validated Applications
WB
Field of Research
Cell Signaling | G Protein Signaling | Small G Proteins | Ras Family | Cell Signaling | Epigenetics and Nuclear Signaling | Transcription | Cancer
Purification
Peptide Affinity Purified
Detection Range
[object Object]
Concentration
1 mg/ml
Dilution
WB (1:1000) ; optimal dilutions for assays should be determined by the user.
Weight
0.1
Buffer
PBS pH 7.4, 50% glycerol, 0.09% sodium azide *Storage buffer changes when conjugated
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Shipping Conditions
Blue Ice or 4ºC
Storage Conditions
-20ºC
Specificity
Detects ~29 kDa. Band is higher than the predicted molecular weight due to post translational modifications.
Species
Rat
Location
Cell Membrane | Lipid-Anchor | Cytoplasmic Side | Cytoplasm | Cytosol
Immunogen Species
Human

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