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ROR1 Antibody

CAT: 0400-SPC-762DSize: 100 µgDry Ice: NoHazardous: No
CAT#:0400-SPC-762DSize:100 µg
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Background
Receptor tyrosine kinase-like orphan receptor 1 (ROR1) is a member of the ROR family of transmembrane proteins involved in non-canonical Wnt signaling. While ROR1 is best known for its role in embryonic development and cancer biology, emerging evidence highlights its significance in the nervous system, particularly in the context of neurodegenerative diseases. In the adult brain, ROR1 expression is typically low but becomes upregulated in response to injury or pathological stress. Recent studies have shown that ROR1 can counteract cytoskeletal degradation induced by amyloid-beta (Aβ1–42), a hallmark of Alzheimer’s disease. Overexpression of ROR1 in neuronal models preserves actin filament integrity, promotes neuritogenesis, and mitigates Aβ-induced cytoskeletal instability. ROR1 is also regulated by non-coding RNAs, including miR-146a and NEAT1, which are dysregulated in Alzheimer’s disease. This regulatory axis suggests that ROR1 is part of a broader epigenetic network influencing neuronal structure and resilience. Additionally, ROR1-mediated signaling may support axonal growth, synaptic maintenance, and neuroregeneration through Wnt5a-dependent pathways. Given its role in maintaining cytoskeletal architecture and responding to neurotoxic stress, ROR1 represents a promising therapeutic target for neurodegenerative diseases. Modulating ROR1 expression or activity could offer novel strategies to preserve neuronal integrity and slow disease progression.
Description
Rabbit Anti-Human ROR1 Polyclonal
CAS Number
9007-83-4
Specifications
Detects 43 kDa. 43 kDa is Isoform 3.
Product Name Alternative
ROR 1, NTRKR1, Neurotrophic tyrosine kinase, OTTMUSP00000008344, Receptor tyrosine kinase like orphan receptor 1, Neurotrophic tyrosine kinase receptor related 1, RP11 24J23.1, Inactive tyrosine-protein kinase transmembrane receptor ROR1, Tyrosine protein kinase transmembrane receptor ROR1, ROR1_HUMAN, Tyrosine-protein kinase transmembrane receptor ROR1, Tyrosine kinase like orphan receptor 1, OTTHUMP00000010574, ROR1, RGD1559469, Neurotrophic tyrosine kinase, receptor related 1, receptor-related 1, dJ537F10.1, OTTHUMP00000010573, MGC99659
UNSPSC
12352203
UN Code
Non-hazardous
Hazard Statement
Non-hazardous
Gene ID
4919
Swiss Prot
Q01973
Accession Number
NP_001077061.1
Cellular Locus
Membrane | Single-Pass Type I Membrane Protein
Host
Rabbit
Species Reactivity
Human
,
Mouse
,
Rat
Immunogen
Synthetic peptide from the mid-protein of Human ROR1 (aa. 200-300)
Target
ROR1
Clonality
Polyclonal
Conjugation
Unconjugated
Tissue Specificity
Expressed strongly in human heart, lung and kidney, but weakly in the CNS. Isoform Short is strongly expressed in fetal and adult CNS and in a variety of human cancers, including those originating from CNS or PNS neuroectoderm.
Type
Polyclonal
Applications
WB | IHC
Validated Applications
WB
,
IHC
Field of Research
Cell Signaling | Protein Phosphorylation | Tyrosine Kinases | Receptor Tyrosine Kinases | Neuroscience
Purification
Peptide Affinity Purified
Detection Range
[object Object]
Concentration
1 mg/ml
Dilution
WB (1:1000) ; IHC (1:50) ; optimal dilutions for assays should be determined by the user.
Weight
0.1
Buffer
PBS pH 7.4, 50% glycerol, 0.09% sodium azide *Storage buffer changes when conjugated
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Chanda, K., Jana, N. R., & Mukhopadhyay, D. (2021) . Receptor tyrosine kinase ROR1 ameliorates Aβ1–42-induced cytoskeletal instability and is regulated by the miR146a-NEAT1 nexus in Alzheimer’s disease. Scientific Reports, 11, 19254. https://doi.org/10.1038/s41598-021-98882-0 2. Makin, S. (2025, April 16) . The future of Alzheimer’s treatment. Nature Outlook: Alzheimer’s Disease. https://www.nature.com/articles/d41586-025-01102-2
Shipping Conditions
Blue Ice or 4ºC
Storage Conditions
-20ºC
Specificity
Detects 43 kDa. 43 kDa is Isoform 3.
Species
Human | Mouse | Rat
Location
Membrane | Single-Pass Type I Membrane Protein
Immunogen Species
Human

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