CCR2 Antibody

CAT: 0400-SPC-704SSize: 12 µgDry Ice: NoHazardous: No
CAT#:0400-SPC-704SSize:12 µg
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Background
C-C chemokine receptor type 2 (CCR2) is a G protein-coupled receptor that plays a pivotal role in regulating immune cell trafficking and neuroinflammatory responses. In the central nervous system (CNS), CCR2 is expressed on monocytes, microglia, and neurons, where it mediates the recruitment of immune cells in response to injury or disease. CCR2 activation facilitates the infiltration of monocytes into the brain and spinal cord, contributing to both protective and pathological outcomes. In neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and amyotrophic lateral sclerosis (ALS), CCR2 signaling influences microglial activation, cytokine release, and the clearance of neurotoxic proteins. While CCR2-mediated immune responses can support tissue repair and amyloid-beta clearance, chronic activation may exacerbate inflammation and neuronal damage. The dual role of CCR2 in neuroprotection and neurotoxicity makes it a compelling target for therapeutic intervention. Inhibiting CCR2 signaling may reduce harmful inflammation, while enhancing its function could promote immune-mediated clearance of pathological aggregates. As a key regulator of immune dynamics in the brain, CCR2 is a promising biomarker and therapeutic target in the development of disease-modifying treatments for neurodegenerative disorders. Its modulation offers a strategic approach to balancing immune surveillance with neuroprotection.
Description
Rabbit Anti-Human CCR2 Polyclonal
CAS Number
9007-83-4
Specifications
Detects ~42 kDa.
Product Name Alternative
CCR2, C-C chemokine receptor type 2, Monocyte chemoattractant protein 1 receptor, CC chemokine receptor type 2, CCR1L, CCCKR2, CD192, MCP-1-R, MCP1 RECEPTOR, CKR2B, C-C CKR-2, CC CKR 2, CD_antigen: CD192, CC-CKR-2, CCR5L, C C chemokine receptor type 2, CD192 antigen, CKR2A, Monocyte chemoattractant protein 1 receptor, CCR 2, CCR2B, C C CKR 2, CCR-2, CMKBR2, MCP 1 R, CCR2A, Chemokine CC Motif Receptor 2, Chemokine C C motif receptor 2, CCR2_HUMAN, MCP1R, CKR 2
UNSPSC
12352203
UN Code
Non-hazardous
Hazard Statement
Non-hazardous
Gene ID
729230
Swiss Prot
P41597
Accession Number
NP_001116513.2
Cellular Locus
Cell Membrane | Multi-Pass Membrane Protein
Host
Rabbit
Species Reactivity
Human, Rat
Immunogen
Synthetic peptide of Human CCR2
Target
CCR2
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Polyclonal
Applications
WB | IHC
Validated Applications
WB, IHC
Field of Research
Immunology | Innate Immunity | Macrophage | Immunology | Innate Immunity | Chemokines | Cell Signaling | Epigenetics and Nuclear Signaling | Nuclear Signaling Pathways | STATs | Cardiovascular System | Atherosclerosis | Vascular Inflammation | Leukocyte Recruitment | Cancer
Purification
Peptide Affinity Purified
Detection Range
A 1:1000 dilution of SPC-704 was sufficient for detection of CCR2 in 15 µg of rat brain cell lysates by ECL immunoblot analysis using goat anti-rabbit IgG:HRP as the secondary antibody.
Concentration
1 mg/ml
Dilution
WB (1:1000) ; IHC (1:50) ; optimal dilutions for assays should be determined by the user.
Weight
0.1
Buffer
PBS, 50% glycerol, 0.09% sodium azide *Storage buffer changes when conjugated
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
Shipping Conditions
Blue Ice or 4ºC
Storage Conditions
-20ºC
Specificity
Detects ~42 kDa.
Species
Human | Rat
Location
Cell Membrane | Multi-Pass Membrane Protein
Immunogen Species
Human

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