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BDNF Antibody

CAT: 0400-SPC-703DSize: 100 µgDry Ice: NoHazardous: No
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CAT#:0400-SPC-703DSize:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Brain-derived neurotrophic factor (BDNF) is a critical member of the neurotrophin family of growth factors, which also includes nerve growth factor (NGF) . Encoded by the BDNF gene, this protein is widely expressed in the central and peripheral nervous systems, where it plays a pivotal role in neuronal survival, differentiation, synaptic plasticity, and long-term memory formation. BDNF is essential for maintaining the structural and functional integrity of neurons throughout life. It supports neurogenesis and modulates synaptic transmission, making it a key regulator of brain plasticity. Altered BDNF expression has been implicated in a range of neurodegenerative disorders, including Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, and amyotrophic lateral sclerosis (ALS) . In motor neuron diseases such as ALS, BDNF has shown potential neuroprotective effects by promoting motor neuron survival and function. Its therapeutic relevance is being actively explored in clinical and preclinical models, where BDNF delivery or upregulation may help counteract progressive neuronal loss. Given its central role in neural health and disease, BDNF is a promising biomarker and therapeutic target in neurodegenerative research. Enhancing BDNF signaling could offer novel strategies for slowing disease progression and promoting neural repair in a variety of neurological conditions.
Description
Rabbit Anti-Human BDNF Polyclonal
CAS Number
9007-83-4
Specifications
Predicted molecular weight at ~27.9kDa.
Product Name Alternative
BDNF, BDNF_HUMAN, Brain-derived neurotrophic factor, Abrineurin, ANON2, MGC34632, Neuronal differentiation factor
UNSPSC
12352203
UN Code
Non-hazardous
Hazard Statement
Non-hazardous
Gene ID
627
Swiss Prot
P23560
Accession Number
NP_001137277.1
Cellular Locus
Secreted
Host
Rabbit
Species Reactivity
Human, Mouse
Immunogen
Synthetic peptide from the N-terminal of human BDNF
Target
BDNF
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Polyclonal
Applications
WB | ICC/IF
Validated Applications
WB, ICC/IF
Field of Research
Neuroscience | Neurodegeneration | Alzheimer's Disease | Cardiovascular System | Atherosclerosis | ALS Disease
Purification
Peptide Affinity Purified
Detection Range
A 1:1000 dilution of SPC-703 was sufficient for detection of BDNF on 293T Rapamycin-treated lysates using Goat anti-rabbit IgG:HRP as the secondary antibody.
Concentration
1 mg/ml
Dilution
WB (1:1000) ; ICC/IF (1:100) ; optimal dilutions for assays should be determined by the user.
Weight
0.1
Buffer
PBS, 50% glycerol, 0.09% sodium azide *Storage buffer changes when conjugated
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Wetmore C., Ernfors P., Persson H., Olson L. (1990) Exp. Neurol. 109 (2) : 141-152. 2. Thoenen H., Zafra F., Hengerer B., Lindholm D. (1991) Ann NY Acad Sci. 640: 86-90. 3. Chun H.S., Son J.J., Son J.H. (2000) Neuroreport. 11 (3) : 511-514.
Shipping Conditions
Blue Ice or 4ºC
Storage Conditions
-20ºC
Specificity
Predicted molecular weight at ~27.9kDa.
Species
Human | Mouse
Location
Secreted
Immunogen Species
Human

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