ATG2A Antibody

Autophagy-related protein 2A (ATG2A) is a core component of the autophagy machinery and a member of the ATG2 protein family, essential for maintaining cellular homeostasis under stress conditions. ATG2A plays a pivotal role in autophagosome biogenesis by facilitating membrane expansion and lipid transfer at the phagophore assembly site. In parallel, ATG2A regulates lipid droplet morphology and dispersion, linking autophagy to lipid metabolism—two processes increasingly recognized as central to neuronal health and disease. In the context of neurodegenerative disorders, ATG2A is emerging as a key player in the cellular response to proteotoxic stress. Impaired autophagy and disrupted lipid homeostasis are hallmark features of diseases such as Alzheimer’s, Parkinson’s, and Huntington’s, where accumulation of misfolded proteins and dysfunctional organelles contributes to neuronal death. By coordinating membrane dynamics and lipid trafficking, ATG2A supports the clearance of toxic aggregates and sustains energy balance in neurons. Recent studies suggest that dysregulation of ATG2A function may exacerbate neurodegenerative pathology by impairing autophagic flux and altering lipid signaling pathways. As such, ATG2A represents a promising target for therapeutic strategies aimed at restoring autophagy and metabolic balance in the aging and diseased brain.

Rabbit Anti-Human ATG2A Polyclonal

9007-83-4

Predicted molecular weights at ~213kDa. Other observed bands around ~90-100kDa to be expected.

ATG2A, KIAA0404, ATG2 autophagy related homolog A, ATG2a_HUMAN, BC023754, 1810013C15Rik

12352203

Non-hazardous

Non-hazardous

23130

Q2TAZ0

NP_055919.2

Preautophagosomal Structure Membrane | Peripheral membrane protein

Synthetic peptide from the C-terminal of human ATG2A

ATG2A

Unconjugated

Polyclonal

WB | ICC/IF

Neuroscience | Cancer | Autophagy | Cardiovascular System | Heart

Peptide Affinity Purified

A 1:1000 dilution of SPC-652 was sufficient for detection of ATG2A on HeLa cell lysates using Goat anti-rabbit IgG:HRP as the secondary antibody.

1 mg/ml

WB (1:1000) ; ICC/IF (1:100) ; optimal dilutions for assays should be determined by the user.

0.1

PBS, 50% glycerol, 0.09% sodium azide *Storage buffer changes when conjugated

Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

1. Velikkakath A.K., Nishimura T., Oita E., Ishihara N., Mizushima N. (2012) Mol Biol Cell. 23 (5) : 896-909.

Blue Ice or 4ºC

-20ºC

Predicted molecular weights at ~213kDa. Other observed bands around ~90-100kDa to be expected.

Human | Mouse

Preautophagosomal Structure Membrane | Peripheral membrane protein