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UVRAG Antibody

CAT: 0400-SPC-606SSize: 12 µgDry Ice: NoHazardous: No
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CAT#:0400-SPC-606SSize:12 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
UVRAG (Ultraviolet irradiation resistance-associated gene) encodes a multifunctional protein that plays a pivotal role in cellular homeostasis, particularly through its regulation of autophagy and endosomal trafficking. As a key activator of the Beclin1–PI3KC3 complex, UVRAG promotes autophagosome formation and maturation, facilitating the clearance of damaged organelles and misfolded proteins—processes that are often disrupted in neurodegenerative diseases. In addition to its autophagic functions, UVRAG contributes to genomic stability by participating in DNA repair and maintaining centrosome integrity. These roles are especially critical in neurons, which are highly sensitive to oxidative stress, DNA damage, and impaired proteostasis. Dysregulation of UVRAG has been linked to pathological features common in neurodegenerative disorders such as Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis. Impaired UVRAG function can lead to defective autophagy, accumulation of toxic protein aggregates, and increased neuronal vulnerability. Given its dual role in autophagy and genome maintenance, UVRAG is emerging as a promising target in neuroscience research. Modulating its activity may offer therapeutic potential for restoring cellular balance, enhancing neuronal survival, and slowing the progression of neurodegenerative diseases.
Description
Rabbit Anti-Human UVRAG Polyclonal
CAS Number
9007-83-4
Specifications
Predicted molecular weight at ~78.1kDa. Observed molecular weights in the 75-90kDa range.
Product Name Alternative
UVRAG, UV radiation resistance-associated, UVRAG_HUMAN, DHTX
UNSPSC
12352203
UN Code
Non-hazardous
Hazard Statement
Non-hazardous
Gene ID
7405
Swiss Prot
Q9P2Y5
Accession Number
NP_003360.2
Cellular Locus
Endosome | Lysosome | Endoplasmic reticulum | Nucleus | Chromosome | Centromere
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Immunogen
Synthetic peptide from the mid-protein of human UVRAG
Target
UVRAG
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Polyclonal
Applications
WB | ICC/IF
Validated Applications
WB, ICC/IF
Field of Research
Cancer | Apoptosis | Autophagy | Cell Signaling | Epigenetics and Nuclear Signaling | Cardiovascular System | Heart
Purification
Peptide Affinity Purified
Detection Range
A 1:1000 dilution of SPC-606 was sufficient for detection of UVRAG on HeLa cell lysates using Goat anti-rabbit IgG:HRP as the secondary antibody.
Concentration
1 mg/ml
Dilution
WB (1:1000) ; ICC/IF (1:100) ; optimal dilutions for assays should be determined by the user.
Weight
0.012
Buffer
PBS, 50% glycerol, 0.09% sodium azide *Storage buffer changes when conjugated
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Liang, C. et al. (2008) Nat Cell Biol. 10: 776-87. 2. Liang, C. et al. (2008) Nat Cell Biol. 10: 776-87. 3. Ionov, Y. et al. (2004) Oncogene. 23: 639-45. 4. Kim, M.S. et al. (2008) Hum Pathol. 39: 1059-63.
Shipping Conditions
Blue Ice or 4ºC
Storage Conditions
-20ºC
Specificity
Predicted molecular weight at ~78.1kDa. Observed molecular weights in the 75-90kDa range.
Species
Human | Mouse | Rat
Location
Endosome | Lysosome | Endoplasmic reticulum | Nucleus | Chromosome | Centromere
Immunogen Species
Human

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