UVRAG Antibody

• Background:

  UVRAG (Ultraviolet irradiation resistance-associated gene) encodes a multifunctional protein that plays a pivotal role in cellular homeostasis, particularly through its regulation of autophagy and endosomal trafficking. As a key activator of the Beclin1–PI3KC3 complex, UVRAG promotes autophagosome formation and maturation, facilitating the clearance of damaged organelles and misfolded proteins—processes that are often disrupted in neurodegenerative diseases. In addition to its autophagic functions, UVRAG contributes to genomic stability by participating in DNA repair and maintaining centrosome integrity. These roles are especially critical in neurons, which are highly sensitive to oxidative stress, DNA damage, and impaired proteostasis. Dysregulation of UVRAG has been linked to pathological features common in neurodegenerative disorders such as Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis. Impaired UVRAG function can lead to defective autophagy, accumulation of toxic protein aggregates, and increased neuronal vulnerability. Given its dual role in autophagy and genome maintenance, UVRAG is emerging as a promising target in neuroscience research. Modulating its activity may offer therapeutic potential for restoring cellular balance, enhancing neuronal survival, and slowing the progression of neurodegenerative diseases.

• Description:

  Rabbit Anti-Human UVRAG Polyclonal

• Specifications:

  Predicted molecular weight at ~78.1kDa. Observed molecular weights in the 75-90kDa range.

• Product Name Alternative:

  UVRAG, UV radiation resistance-associated, UVRAG_HUMAN, DHTX

• UNSPSC:

  12352203

• UN Code:

  Non-hazardous

• Hazard Statement:

  Non-hazardous

• Gene ID:

  7405

• Swiss Prot:

  Q9P2Y5

• Accession Number:

  NP_003360.2

• Cellular Locus:

  Endosome | Lysosome | Endoplasmic reticulum | Nucleus | Chromosome | Centromere

• Host:

  Rabbit

• Species Reactivity:

  Human, Mouse, Rat

• Immunogen:

  Synthetic peptide from the mid-protein of human UVRAG

• Target:

  UVRAG

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Type:

  Polyclonal

• Applications:

  WB | ICC/IF

• Validated Applications:

  WB, ICC/IF

• Field of Research:

  Cancer | Apoptosis | Autophagy | Cell Signaling | Epigenetics and Nuclear Signaling | Cardiovascular System | Heart

• Purification:

  Peptide Affinity Purified

• Detection Range:

  A 1:1000 dilution of SPC-606 was sufficient for detection of UVRAG on HeLa cell lysates using Goat anti-rabbit IgG:HRP as the secondary antibody.

• Concentration:

  1 mg/ml

• Dilution:

  WB (1:1000) ; ICC/IF (1:100) ; optimal dilutions for assays should be determined by the user.

• Weight:

  0.012

• Buffer:

  PBS, 50% glycerol, 0.09% sodium azide *Storage buffer changes when conjugated

• Precautions:

  Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.

• References & Citations:

  1. Liang, C. et al. (2008) Nat Cell Biol. 10: 776-87. 2. Liang, C. et al. (2008) Nat Cell Biol. 10: 776-87. 3. Ionov, Y. et al. (2004) Oncogene. 23: 639-45. 4. Kim, M.S. et al. (2008) Hum Pathol. 39: 1059-63.

• Shipping Conditions:

  Blue Ice or 4ºC

• Storage Conditions:

  -20ºC

• Specificity:

  Predicted molecular weight at ~78.1kDa. Observed molecular weights in the 75-90kDa range.

• Species:

  Human | Mouse | Rat

• CAS Number:

  9007-83-4

• Location:

  Endosome | Lysosome | Endoplasmic reticulum | Nucleus | Chromosome | Centromere

• Immunogen Species:

  Human