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HSP110 Antibody (APC)

CAT: 0013-GTR18029378Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0013-GTR18029378Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Rabbit polyclonal to Hsp110 (APC) . Hsp110 belongs to a family of large stress proteins known as the Hsp110/SSE Family. The proteins in this family are the most distantly known relatives of the well studied Hsp70 family. They share 30-33% amino acid identity, mostly in the conserved ATP-binding domain. Hsp110 cooperates with Hsp70 in protein folding in the eukaryotic cytosol. In mammals, Hsp110 is constitutively expressed, but exhibits particularly high levels in the brain. Both Hsp70 and Hsp110 are elevated after cerebral ischemia. Recent studies demonstrate that the protective effects of Hsp110 deficiency in cerebral ischemia may partly be mediated by an increase in the chaperone activity of Hsp70. Studies also suggest that Hsp110 can be used in heat shock protein-based cancer immunotherapy..
Product Name Alternative
HSPH1, HSP110, HSP105, Heat shock protein 105 kDa, Heat shock 110 kDa protein, KIAA0201, Heat shock 105kDa alpha, heat shock 105kDa beta, HSP105A, HSP105B, NY CO 25
UniProt
Q92599
Reactivity
Bovine, Fish, Hamster, Human, Monkey, Mouse, Rat, Sheep, Yeast
Immunogen
Synthetic peptide derived from the sequence of hamster HSP110; sequence identical to human and mouse
Target
HSP110
Clonality
Polyclonal
Conjugation
APC
Field of Research
Cancer Biology, Cell Biology, Protein Biochemistry, Signal Transduction
Purification
Protein A Purified
Concentration
1 mg/ml
Dilution
WB (1:1000), IHC (1:100)
Molecular Weight
110kDa
Storage Conditions
Conjugated antibodies should be stored according to the product label
Notes
For research use only.
Applications Notes
1 μg/ml was sufficient for detection of HSP110 in 10 μg of human cell line mixed lysate by colorimetric immunoblot analysis using Goat anti-rabbit IgG:HRP as the secondary antibody.
Tested Applications
ICC, IF, IHC, WB
NCBI Accession Number
NP_006635.3
Host or Source
Rabbit
Preservative
95.46mM Phosphate, 2.48mM MES and 2mM EDTA
Entrez
10808

UniProtKB · Q92599

Septin-8

SEPT8_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q92599
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
SEPTIN8
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
A6NC65, A6NKP6, F6W7K9, Q8IX36, Q8IX37, Q9BVB3
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationPhosphoprotein

Coding sequence diversity

Alternative splicing

Cellular component

Cell projectionCytoplasmCytoplasmic vesicleCytoskeletonMembraneSynapse

Domain

Coiled coil

Ligand

GTP-bindingNucleotide-binding

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