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Phosphothreonine Antibody

CAT: 0400-SPC-154FSize: 400 µLDry Ice: NoHazardous: No
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CAT#:0400-SPC-154FSize:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Phosphothreonine is a phosphorylated derivative of threonine, catalyzed by serine/threonine kinases. It serves as a regulatory switch in numerous signaling pathways that govern neuronal survival, synaptic function, and stress responses. In the brain, phosphothreonine modifications influence the activity of key proteins such as tau, MAPKs, and transcription factors. Dysregulated threonine phosphorylation is associated with protein misfolding, impaired axonal transport, and neuroinflammation—hallmarks of neurodegenerative diseases. Notably, abnormal phosphorylation of tau at threonine residues contributes to its aggregation and toxicity in Alzheimer’s disease. As a modifiable and site-specific event, phosphothreonine is a valuable marker for disease progression and a potential target for kinase-based therapies in neurodegeneration.
Description
Rabbit Anti-Phosphothreonine Polyclonal
CAS Number
9007-83-4
Specifications
Detects proteins phosphorylated on threonine residues. Does not cross-react with phosphotyrosine.
Product Name Alternative
O-phospho-L-threonine, Phospho-threonine
UNSPSC
12352203
UN Code
Non-hazardous
Hazard Statement
Non-hazardous
Host
Rabbit
Species Reactivity
Species Independent
Immunogen
Phosphothreonine conjugated to KLH
Target
Phosphothreonine
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Polyclonal
Applications
WB | ICC/IF | IP | ELISA
Validated Applications
WB, ICC/IF, IP, ELISA
Field of Research
Cell Signaling | Post-translational Modifications | Phosphorylation
Purification
Peptide Affinity Purified
Detection Range
2 µg/ml of SPC-154 was sufficient for detection of phosphorylation signal in western blot analysis using mouse spleen extract treated with Vanadium.
Concentration
0.25 mg/ml
Dilution
WB (1:500), ICC/IF (1:60), ELISA (1:2000), IP (1:100) ; optimal dilutions for assays should be determined by the user.
Weight
0.4
Buffer
PBS, 50% glycerol, 0.01% sodium azide *Storage buffer changes when conjugated
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Goto H. et al. (2005) Nature Cell Biology 8: 180-187. 2. Blume-Jensen P. and Hunter T. (2001) Nature 411: 355-365. 3. Downward J. (2001) Nature 411: 759-762. 4. Pawson T. and Saxton T.M. (1999) Cell 97: 675-678. 5. Ostrovsky P.C. (1995) Genes Dev. 9 (16) : 2034-2041.
Shipping Conditions
Blue Ice or 4ºC
Storage Conditions
-20ºC
Specificity
Detects proteins phosphorylated on threonine residues. Does not cross-react with phosphotyrosine.
Species
Species Independent

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