Products for Research Use Only
RegisterLogin

P38 Antibody

CAT: 0400-SPC-172DSize: 100 µLDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0400-SPC-172DSize:100 µL
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
P38 is a member of the mitogen-activated protein kinase (MAPK) family, specifically involved in cellular responses to stress and inflammation. In the nervous system, p38 plays a pivotal role in regulating apoptosis, neuroinflammation, and synaptic plasticity—processes that are frequently dysregulated in neurodegenerative diseases. Upon activation by environmental and cellular stressors such as oxidative damage, cytokines, and UV radiation, p38 translocates to the nucleus where it modulates transcription factors and pro-apoptotic proteins. This leads to the release of cytochrome c, activation of caspase-3, and cleavage of PARP, promoting programmed cell death. In Alzheimer’s, Parkinson’s, and ALS, aberrant p38 signaling contributes to neuronal loss, glial activation, and neurodegenerative phenotypes. As a result, p38 has emerged as a therapeutic target for modulating neuroinflammation and preventing neuronal degeneration.
Description
Rabbit Anti-Human p38 Polyclonal
CAS Number
9007-83-4
Specifications
Detects ~43kDa.
Product Name Alternative
CSAID Binding protein 1, CSBP1, CSBP2, EXIP, MAP kinase MXI2, MAPkinase p38alpha, MAPK14, p38 ALPHA, p38 MAP kinase, p38 mitogen activated protein kinase, RK, SAPK 2A, Stress activated protein kinase 2A
UNSPSC
12352203
UN Code
Non-hazardous
Hazard Statement
Non-hazardous
Gene ID
1432
Swiss Prot
Q16539
Accession Number
NP_001306.1
Cellular Locus
Cytoplasm | Nucleus
Host
Rabbit
Species Reactivity
Human, Mouse, Rat, Bovine, Monkey, Rabbit, Pig, Dog, Hamster, Chicken, Sheep, Guinea pig
Immunogen
A 20 residue synthetic peptide based on the human p38 with the cysteine residue added and coupled to KLH
Target
p38
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Polyclonal
Applications
WB | IHC | ICC/IF | IP
Validated Applications
WB, IHC, ICC/IF, IP
Field of Research
Cell Signaling | Post-translational Modifications | Phosphorylation | Cancer
Purification
Peptide Affinity Purified
Detection Range
A 1:1000 dilution of SPC-172 was sufficient for detection of p38 in 20 µg of HeLa cell lysate by ECL immunoblot analysis.
Concentration
1 mg/ml
Dilution
WB (1:1000), ICC/IF (1:100), IP (1:250) ; optimal dilutions for assays should be determined by the user.
Weight
0.1
Buffer
PBS pH7.4, 50% glycerol, 0.09% sodium azide *Storage buffer changes when conjugated
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Pearson G., et al (2001) Endocrine Reviews 22 (2) : 153-183. 2. Fan Y., et al (2007) Mol. Cells 23 (1) : 30-38. 3. Han J., et al. (1994) Science 265: 808-811. 4. Van L. A., et al. (2004) Faseb J. 18: 1946−1948. 5. Deng et al. (2003) Cell 115: 61-70. 6. Salojin K.V., et al. (2006) J Immunol. 176 (3) :1899-907. 7. Medicherla S., et al. (2006) J Pharmacol Exp Ther. 318 (1) : 99-107.
Shipping Conditions
Blue Ice or 4ºC
Storage Conditions
-20ºC
Specificity
Detects ~43kDa.
Species
Human | Mouse | Rat | Bovine | Monkey | Rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus)
Location
Cytoplasm | Nucleus
Immunogen Species
Human

Related Products

CatalogName
SMC-152DP38 alpha MAPK Antibody, Clone 9F12
SMC-152SP38 alpha MAPK Antibody, Clone 9F12
SMC-152D-RPEP38 alpha MAPK Antibody, Clone 9F12: RPE
SMC-152D-APCP38 alpha MAPK Antibody, Clone 9F12: APC
SMC-152D-PCPP38 alpha MAPK Antibody, Clone 9F12: PerCP
SMC-152D-BIP38 alpha MAPK Antibody, Clone 9F12: Biotin
SMC-152D-FITCP38 alpha MAPK Antibody, Clone 9F12: FITC
SMC-152D-HRPP38 alpha MAPK Antibody, Clone 9F12: HRP
SMC-152D-A594P38 alpha MAPK Antibody, Clone 9F12: ATTO 594
SMC-152D-A390P38 alpha MAPK Antibody, Clone 9F12: ATTO 390

Alternative Products

CatalogName
MBS8529199-01H2B Antibody Antibody
MBS8513599-01CD11b Antibody Antibody
MBS850197-01Antibody to IGFBP2 Antibody
DF8746-01ASAP1 antibody Antibody
E36403ZNF98 Antibody Antibody
GWB-250026Lck antibody Antibody
E8M1007-4HSP60 Antibody Antibody
MBS9403836-01SZT2 Antibody Antibody
LSMab09882anti-Antibody^Polyclonal antibody control antibody
GWB-5C6547MAD1L1 antibody [9B10] Antibody

Popular Products