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Phosphoserine Antibody

CAT: 0400-SPC-149FSize: 400 µLDry Ice: NoHazardous: No
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CAT#:0400-SPC-149FSize:400 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Phosphoserine is a post-translationally modified form of the amino acid serine, resulting from phosphorylation by serine/threonine kinases. This modification plays a critical role in regulating protein function, localization, and interactions, particularly in the central nervous system. In neurons, phosphoserine is involved in signal transduction, synaptic plasticity, and cytoskeletal dynamics. Aberrant serine phosphorylation has been implicated in the pathogenesis of neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and ALS. For example, hyperphosphorylation of tau protein at serine residues contributes to neurofibrillary tangle formation and neuronal dysfunction in Alzheimer’s disease. Phosphoserine also modulates the activity of transcription factors, ion channels, and enzymes involved in oxidative stress responses and apoptosis. As a dynamic and reversible modification, it offers a promising target for therapeutic intervention and biomarker development in neurodegeneration.
Description
Rabbit Anti-Phosphoserine Polyclonal
CAS Number
9007-83-4
Specifications
Detects proteins phosphorylated on serine residues. Does not cross-react with phosphotyrosine.
Product Name Alternative
O-phospho-L-serine, Phospho-serine, OPS, Phospho-ser, pS, pSer
UNSPSC
12352203
UN Code
Non-hazardous
Hazard Statement
Non-hazardous
Host
Rabbit
Species Reactivity
Species Independent
Immunogen
Phosphoserine conjugated to KLH, and phosvitin mixture
Target
Phosphoserine
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Polyclonal
Applications
WB | IHC | ICC/IF | IP | ELISA
Validated Applications
WB, IHC, ICC/IF, IP, ELISA
Field of Research
Cell Signaling | Post-translational Modifications | Phosphorylation
Purification
Peptide Affinity Purified
Detection Range
2 µg/ml of SPC-149 was sufficient for detection of phosphorylation signal in western blot analysis using human MMRU cells treated with 0.1 µM okadaic acid.
Concentration
0.25 mg/ml
Dilution
WB (1:500), ICC/IF (1:50), ELISA (1:250), IP (1:100) ; optimal dilutions for assays should be determined by the user.
Weight
0.4
Buffer
PBS, 50% glycerol, 0.01% sodium azide *Storage buffer changes when conjugated
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. Goto H. et al. (2005) Nature Cell Biology 8: 180-187. 2. Blume-Jensen P. and Hunter T. (2001) Nature 411: 355-365. 3. Downward J. (2001) Nature 411: 759-762. 4. Pawson T. and Saxton T.M. (1999) Cell 97: 675-678. 5. Ostrovsky P.C. (1995) Genes Dev. 9 (16) : 2034-2041.
Shipping Conditions
Blue Ice or 4ºC
Storage Conditions
-20ºC
Specificity
Detects proteins phosphorylated on serine residues. Does not cross-react with phosphotyrosine.
Species
Species Independent

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