Products for Research Use Only
RegisterLogin

PDI Antibody

CAT: 0400-SPC-114SSize: 12 µLDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0400-SPC-114SSize:12 µL
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
Protein disulfide isomerase (PDI) is a thiol-disulfide oxidoreductase that facilitates protein folding and quality control in the endoplasmic reticulum (ER) . In neurons, PDI plays a protective role by preventing the accumulation of misfolded proteins and maintaining redox homeostasis. Under conditions of ER stress—common in neurodegenerative diseases—PDI expression is upregulated as part of the unfolded protein response (UPR) . However, excessive or dysfunctional PDI activity has been linked to protein aggregation and oxidative damage in Alzheimer’s, ALS, and Parkinson’s disease. PDI’s dual role in neuroprotection and pathology makes it a compelling target for therapeutic strategies aimed at modulating ER stress and proteostasis in neurodegeneration.
Description
Rabbit Anti-Rat PDI Polyclonal
CAS Number
9007-83-4
Specifications
Detects ~58kDa.
Product Name Alternative
Thioredoxin domain containing 5, ERP46, UNQ364, MGC3178, FLJ21353, FLJ90810, thioredoxin related protein, endothelial protein disulphide isomeras
UNSPSC
12352203
UN Code
Non-hazardous
Hazard Statement
Non-hazardous
Swiss Prot
P04785
Cellular Locus
Endoplasmic Reticulum | Endoplasmic Reticulum Lumen
Host
Rabbit
Species Reactivity
Human, Mouse, Rat, Bovine, Dog, Hamster, Guinea Pig, Sheep, Pig, Xenopus, Mollusk
Immunogen
AA499-509 of Rat PDI
Target
PDI
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Polyclonal
Applications
WB | IHC | ICC/IF | IP
Validated Applications
WB, IHC, ICC/IF, IP
Field of Research
Cell Signaling | Protein Trafficking | Chaperone Proteins | Tags and Cell Markers | Organelle Markers
Purification
Protein A purified
Detection Range
A 1:1000 dilution of SPC-114 was sufficient for detection of PDI in 20 µg of HeLa cell lysate by ECL immunoblot analysis.
Concentration
1 mg/ml
Dilution
WB (1:1000), ICC/IF (1:100) ; optimal dilutions for assays should be determined by the user.
Weight
0.012
Buffer
PBS pH7.4, 50% glycerol, 0.09% sodium azide *Storage buffer changes when conjugated
Precautions
Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
References & Citations
1. NA K.S. et al. (2007) Mol Cells. 24 (2) : 261-7. 2. Mayer M., Kies U., Kammermeier R., and Buchner J. (2000) J Biol Chem. 275 (38) : 29421-5. 3. Delom F., Mallet B., Carayon P., and Lejeune P.J. (2001) J Biol Chem 276 (24) : 21337-42. 4. Schultz-Norton J.R., McDonald W.H., Yates J.R. and Nardulli A.M. (2006) Mol Endocrinol 20 (9) : 1982-95. 5. Turano C., Coppari S. Altieri F. and Ferraro (2002) J Cell Physiol 193: 154-163. 6. Janiszewski M. (2005) J. Biol Chem. 280 (49) : 40813- 40819. 7. Yoshimori T., et al. (1990) J Biol Chem. 265 (26) : 15984-90.
Shipping Conditions
Blue Ice or 4ºC
Storage Conditions
-20ºC
Specificity
Detects ~58kDa.
Species
Human | Mouse | Rat | Bovine | Dog | Hamster | Guinea Pig (Cavia porcellus) | Sheep | Pig | African clawed frog (Xenopus laevis) | Mollusk | Mussel (Perna viridis)
Location
Endoplasmic Reticulum | Endoplasmic Reticulum Lumen
Immunogen Species
Rat

Related Products

CatalogName
SPC-741DPIK3CA Antibody
SPC-195SHSP110 Antibody
SPC-668DRubicon Antibody
SMC-612SRAB1A Antibody
SPC-668SRubicon Antibody
SPC-198DBassoon Antibody
SMC-534DCrotonaldehyde Antibody
SPC-704DCCR2 Antibody
SPC-183DAHA1 Antibody
SPC-400DNHE3 Antibody

Alternative Products

CatalogName
MBS8529199-01H2B Antibody Antibody
MBS8513599-01CD11b Antibody Antibody
MBS850197-01Antibody to IGFBP2 Antibody
DF8746-01ASAP1 antibody Antibody
E36403ZNF98 Antibody Antibody
GWB-250026Lck antibody Antibody
E8M1007-4HSP60 Antibody Antibody
MBS9403836-01SZT2 Antibody Antibody
LSMab09882anti-Antibody^Polyclonal antibody control antibody
GWB-5C6547MAD1L1 antibody [9B10] Antibody

Popular Products