CQ-Mito

• Description :

  CQ-Mito is a Coumarin-Quinazolinone (CQ) -based derivative that targets mitochondria and exhibits profound phototherapeutic performances with an Phototoxic Index (PI) value of 167. CQ-Mito causes cell death by both apoptosis and ferroptosis. CQ-Mito mediates mitochondrial dysfunction, including mitochondrial morphology changed and the loss of MMP. CQ-Mito can efficiently inhibit the tumor growth in organoid tumor models[1].

• UNSPSC :

  12352005

• Target :

  Apoptosis; Ferroptosis; MMP

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; Metabolic Enzyme/Protease

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/cq-mito.html

• Smiles :

  O=C(C(C1=NC2=CC=C(OCC3=CN(CCC[P+](C4=CC=CC=C4)(C5=CC=CC=C5)C6=CC=CC=C6)N=N3)C=C2C(N1)=O)=C7)OC8=C7C=CC(N(CC)CC)=C8.[Br-]

• Molecular Formula :

  C45H42BrN6O4P

• Molecular Weight :

  841.73

• References & Citations :

  [1]Zhao X, et al. Coumarin-Quinazolinone based photosensitizers: Mitochondria and endoplasmic reticulum targeting for enhanced phototherapy via different cell death pathways. Eur J Med Chem. 2024 Dec 15;280:116990.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported