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CQ-Mito

CAT: 0804-HY-168260Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-168260Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CQ-Mito is a Coumarin-Quinazolinone (CQ) -based derivative that targets mitochondria and exhibits profound phototherapeutic performances with an Phototoxic Index (PI) value of 167. CQ-Mito causes cell death by both apoptosis and ferroptosis. CQ-Mito mediates mitochondrial dysfunction, including mitochondrial morphology changed and the loss of MMP. CQ-Mito can efficiently inhibit the tumor growth in organoid tumor models[1].
UNSPSC
12352005
Target
Apoptosis; Ferroptosis; MMP
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cq-mito.html
Smiles
O=C(C(C1=NC2=CC=C(OCC3=CN(CCC[P+](C4=CC=CC=C4)(C5=CC=CC=C5)C6=CC=CC=C6)N=N3)C=C2C(N1)=O)=C7)OC8=C7C=CC(N(CC)CC)=C8.[Br-]
Molecular Formula
C45H42BrN6O4P
Molecular Weight
841.73
References & Citations
[1]Zhao X, et al. Coumarin-Quinazolinone based photosensitizers: Mitochondria and endoplasmic reticulum targeting for enhanced phototherapy via different cell death pathways. Eur J Med Chem. 2024 Dec 15;280:116990.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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