CQ-16

CAT: 0804-HY-169336Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-169336Size:1 Each
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Description
CQ-16 is an orally active small molecule drug conjugate (SMDC) targeting prostate-specific membrane antigen (PSMA) . CQ-16 exhibits highly selective antiproliferative activity between PSMA-positive and PSMA-negative prostate cells. In addition, CQ-16 also has PARP inhibitory activity (IC50=1 nM) . (Pink: PSMA Ligand (HY-139840) ; Black: Linker (HY-W037980) ; Blue: PARP Inhibitor (HY-10162) ) [1]
CAS Number
[3024354-59-1]
UNSPSC
12352005
Target
PARP; PSMA
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cq-16.html
Smiles
O=C1NN=C(C2=CC=CC=C21)CC3=CC=C(C(C(N4CCN(CC4)C(C5(NC(CCC(NCCCC[C@H](NC(N[C@H](C(O)=O)CCC(O)=O)=O)C(O)=O)=O)=O)CC5)=O)=O)=C3)F
Molecular Formula
C40H47FN8O12
Molecular Weight
850.85
References & Citations
[1]Chen Q, et al. A Prostate-Specific Membrane Antigen-Targeting Small Molecule–Drug Conjugate Strategy to Overcome the Hematological Toxicity of Olaparib[J]. Journal of Medicinal Chemistry, 2024.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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