PI3Kδ-IN-20

PI3Kδ-IN-20

• UNSPSC Description: PI3Kδ-IN-20 (compound (S)-36) is a potent inhibitor of PI3Kδ, with the IC50 of 6.4 nM. PI3Kδ-IN-20 has oral bioactivity. PI3Kδ-IN-20 shows significant suppression of cell proliferation and remarkable induction of apoptosis both in vitro and in vivo[1].
• Target Antigen: PI3K
• Type: Reference compound
• Related Pathways: PI3K/Akt/mTOR
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/pi3kδ-in-20.html
• Solubility: 10 mM in DMSO
• Smiles: CC1=NN([C@H](C2=NN(C3=CC(Cl)=CC=C23)C4=CC=NC=C4)C)C5=C1C(N)=NC=N5
• Molecular Weight: 404.86
• References & Citations: [1]Yongmei Tang, et al. Discovery of Potent and Selective PI3Kδ Inhibitors for the Treatment of Acute Myeloid Leukemia. J Med Chem. 2024 Apr 25;67(8):6638-6657.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported