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PI3Kδ-IN-20

CAT: 0804-HY-158147Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-158147Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PI3Kδ-IN-20 (compound (S) -36) is a potent inhibitor of PI3Kδ, with the IC50 of 6.4 nM. PI3Kδ-IN-20 has oral bioactivity. PI3Kδ-IN-20 shows significant suppression of cell proliferation and remarkable induction of apoptosis both in vitro and in vivo[1].
UNSPSC
12352005
Target
PI3K
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pi3kδ-in-20.html
Solubility
10 mM in DMSO
Smiles
CC1=NN([C@H](C2=NN(C3=CC(Cl)=CC=C23)C4=CC=NC=C4)C)C5=C1C(N)=NC=N5
Molecular Formula
C20H17ClN8
Molecular Weight
404.86
References & Citations
[1]Yongmei Tang, et al. Discovery of Potent and Selective PI3Kδ Inhibitors for the Treatment of Acute Myeloid Leukemia. J Med Chem. 2024 Apr 25;67 (8) :6638-6657.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PI3Kδ

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