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Thalidomide-4-OH-C11-OH

CAT: 0804-HY-174087Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-174087Size:1 Each
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Description
Thalidomide-4-OH-C11-OH is an E3 Ligase Ligand-Linker Conjugate, which is composed of Thalidomide-4-OH and the corresponding Linker. Thalidomide-4-OH-C11-OH can be used as a Cereblon ligand to recruit CRBN protein and as a key intermediate for the synthesis of complete PROTACs molecules, such as PROTAC GPX4 degrader-4 (HY-174086).
CAS Number
3071165-50-6
UNSPSC
12352005
Target
E3 Ligase Ligand-Linker Conjugates
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=C1N(C(C2=C(C=CC=C21)OCCCCCCCCCCCO)=O)C3CCC(NC3=O)=O
Molecular Formula
C24H32N2O6
Molecular Weight
444.52
References & Citations
[1]Yang X, et al. Discovery of Artesunate (ARS) PROTACs as GPX4 protein degraders for the treatment of bladder cancer. Eur J Med Chem. 2025 Sep 5;293:117710.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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