KRpep-2d (TFA)

• UNSPSC Description:

  KRpep-2d (TFA) is a potent K-Ras inhibitor and inhibits proliferation of K-Ras-driven cancer cells. KRpep-2d can be used for cancer research[1].

• Target Antigen:

  Ras

• Type:

  Peptides

• Related Pathways:

  GPCR/G Protein;MAPK/ERK Pathway

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/krpep-2d-tfa.html

• Purity:

  98.11

• Solubility:

  10 mM in DMSO|H2O : 100 mg/mL (ultrasonic)

• Smiles:

  O=C1N2[C@@](C(N[C@H](C(N[C@H](C(N[C@@](C(N[C@H](C(N[C@H](C(N[C@H](C(N3[C@](CCC3)([H])C(N[C@H](C(N[C@@H](CSSC[C@@H]1NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC([C@@H](NC(C)=O)CCCNC(N)=N)=O)=O)=O)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N)=O)CCCNC(N)=N)=O)=O)=O)=O)=O)C(C)C)=O)=O)CC(O)=O)=O)CC4=CC=C(C=C4)O)=O)CO)=O)([H])[C@@H](C)CC)=O)CC5=CC=C(C=C5)O)=O)CC(C)C)=O)([H])CCC2.OC(C(F)(F)F)=O

• Molecular Weight:

  2675.03

• References & Citations:

  [1]Niida A, et al. Investigation of the structural requirements of K-Ras(G12D) selective inhibitory peptide KRpep-2d using alanine scans and cysteine bridging. Bioorg Med Chem Lett. 2017 Jun 15;27(12):2757-2761.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light, under nitrogen)

• Clinical Information:

  No Development Reported