KRpep-2d

• Description :

  KRpep-2d is a potent K-Ras inhibitor and inhibits proliferation of K-Ras-driven cancer cells. KRpep-2d can be used for cancer research[1].

• UNSPSC :

  12352209

• Target :

  Ras

• Type :

  Peptides

• Related Pathways :

  GPCR/G Protein; MAPK/ERK Pathway

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/krpep-2d.html

• Purity :

  95.09

• Solubility :

  H2O : 50 mg/mL (ultrasonic)

• Smiles :

  O=C1N2C(CCC2)(C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC3=CC=C(O)C=C3)C(=O)N[C@@]([C@H](CC)C)(C(=O)N[C@@H](CO)C(=O)N[C@@H](CC4=CC=C(O)C=C4)C(=O)N[C@@H](CC(O)=O)C(=O)N5[C@](C(=O)N[C@@H](C(C)C)C(=O)N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CCCNC(=N)N)C(N)=O)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CSSC[C@@H]1NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CCCNC(=N)N)NC(C)=O)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)CCCNC(=N)N)=O)(CCC5)[H])[H])[H]

• Molecular Formula :

  C108H182N44O25S2

• Molecular Weight :

  2561.02

• References & Citations :

  [1]Niida A, et al. Investigation of the structural requirements of K-Ras (G12D) selective inhibitory peptide KRpep-2d using alanine scans and cysteine bridging. Bioorg Med Chem Lett. 2017 Jun 15;27 (12) :2757-2761.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light, under nitrogen)

• Scientific Category :

  Peptides

• Clinical Information :

  No Development Reported

• Isoform :

  K-Ras

• CAS Number :

  [2098181-84-9]