EXQ-2d

• Description :

  EXQ-2d is the inhibitor for tankyrase and inhibits TNKS1 and TNKS2 with an IC50 of 48.8 nM and 13.8 nM (pIC50=7.31 and 7.86) . EXQ-2d inhibits WNT/β-catenin signaling pathway with IC50 of 515 nM. EXQ-2d exhibits anti-proliferative activity in cancer cells COLO 320DM and RKO with GI50 of 4.9 μM and 77 μM[1].

• UNSPSC :

  12352005

• Target :

  PARP; Wnt; β-catenin

• Related Pathways :

  Cell Cycle/DNA Damage; Epigenetics; Stem Cell/Wnt

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Smiles :

  O=C1NC(C2=CC=C(C(C)(C)C)C=C2)=NC3=C([N+]([O-])=O)C=CC=C31

• Molecular Formula :

  C18H17N3O3

• Molecular Weight :

  323.35

• References & Citations :

  [1]Bosetti C, et al., Substitutions at the C-8 position of quinazolin-4-ones improve the potency of nicotinamide site binding tankyrase inhibitors. Eur J Med Chem. 2025 Feb 15;288:117397.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  TNKS1/PARP5A; TNKS2/PARP5B