Ac-IEPD-CHO

• UNSPSC Description:

  Ac-IEPD-CHO is a reversible granzyme B inhibitor with a Ki of 80 nM[1]. Ac-IEPD-CHO is also a caspase-8 inhibitor[2].

• Target Antigen:

  Caspase

• Type:

  Peptides

• Related Pathways:

  Apoptosis

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/ac-iepd-cho.html

• Purity:

  99.61

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)

• Smiles:

  CC[C@H](C)[C@H](NC(C)=O)C(N[C@@H](CCC(O)=O)C(N1[C@@H](CCC1)C(N[C@H](C=O)CC(O)=O)=O)=O)=O

• Molecular Weight:

  498.53

• References & Citations:

  [1]Mi-Sun Kim, et al. Approaches to design non-covalent inhibitors for human granzyme B (hGrB). Org Biomol Chem. 2014 Nov 28;12(44):8952-65.|[2]In-Sun Hong, et al. Gonadotropin-releasing hormones I and II induce apoptosis in human granulosa cells. J Clin Endocrinol Metab. 2008 Aug;93(8):3179-85.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

• Clinical Information:

  No Development Reported

• CAS Number:

  352520-90-2