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Esomeprazole-d3 (potassium)

CAT: 0804-HY-17021S2Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-17021S2Size:1 Each
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Description
Esomeprazole-d3 potassium is deuterated labeled Esomeprazole. Esomeprazole ((S) -Omeprazole) is a potent and orally active proton pump inhibitor and reduces acid secretion through inhibition of the H+, K+-ATPase in gastric parietal cells. Esomeprazole has the potential for symptomatic gastroesophageal reflux disease research[1][2][3].
Product Name Alternative
(S) -Omeprazole-d3 (potassium) ; (-) -Omeprazole-d3 (potassium)
UNSPSC
12352005
Target
Bacterial; Isotope-Labeled Compounds; Proton Pump
Type
Isotope-Labeled Compounds
Related Pathways
Anti-infection; Membrane Transporter/Ion Channel; Others
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cancer; Endocrinology; Inflammation/Immunology
Solubility
10 mM in DMSO
Smiles
O=[S@@](CC1=NC=C(C(OC)=C1C)C)C2=NC3=CC(OC([2H])([2H])[2H])=CC=C3N2[K]
Molecular Formula
C17H15D3KN3O3S
Molecular Weight
386.52
References & Citations
[1]Wayne Goh, et al. Use of proton pump inhibitors as adjunct treatment for triple-negative breast cancers. An introductory study. J Pharm Pharm Sci. 2014;17 (3) :439-46.|[2]Christina Nelson, et al. Therapeutic Efficacy of Esomeprazole in Cotton Smoke-Induced Lung Injury Model. Front Pharmacol. 2017 Jan 26;8:16.|[3]Thomas J Johnson, et al. Esomeprazole: a clinical review. Am J Health Syst Pharm. 2002 Jul 15;59 (14) :1333-9.|[4]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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