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Esomeprazole-d3

CAT: 0804-HY-17021S1Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-17021S1Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Esomeprazole-d3 is deuterium labeled Esomeprazole. Esomeprazole ((S) -Omeprazole) is a potent and orally active proton pump inhibitor and reduces acid secretion through inhibition of the H+, K+-ATPase in gastric parietal cells. Esomeprazole has the potential for symptomatic gastroesophageal reflux disease research[1][2][3].
Product Name Alternative
(S) -Omeprazole-d3; (-) -Omeprazole-d3
UNSPSC
12352005
Target
Isotope-Labeled Compounds; Proton Pump
Type
Isotope-Labeled Compounds
Related Pathways
Membrane Transporter/Ion Channel; Others
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cancer; Endocrinology; Inflammation/Immunology
Purity
99.71
Solubility
10 mM in DMSO
Smiles
O=[S@](C1=NC2=C([2H])C([2H])=C(OC)C([2H])=C2N1)CC3=NC=C(C)C(OC)=C3C
Molecular Formula
C17H16D3N3O3S
Molecular Weight
348.43
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Christina Nelson, et al. Therapeutic Efficacy of Esomeprazole in Cotton Smoke-Induced Lung Injury Model. Front Pharmacol. 2017 Jan 26;8:16.|[3]Thomas J Johnson, et al. Esomeprazole: a clinical review. Am J Health Syst Pharm. 2002 Jul 15;59 (14) :1333-9.|[4]Wayne Goh, et al. Use of proton pump inhibitors as adjunct treatment for triple-negative breast cancers. An introductory study. J Pharm Pharm Sci. 2014;17 (3) :439-46.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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