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Apaf-1 Polyclonal Antibody

CAT: 0749-ABP53109-01Size: 30 µLDry Ice: NoHazardous: No
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CAT#:0749-ABP53109-01Size:30 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
APAF1 encodes a cytoplasmic protein that initiates apoptosis. Apoptotic protease-activating factor 1 contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC) . Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms.
Description
Rabbit Anti-Apaf-1 Polyclonal Antibody
CAS Number
9007-83-4
Product Name Alternative
APAF1; KIAA0413; Apoptotic protease-activating factor 1; APAF-1
Gene ID
317
Accession Number
O14727
Reactivity
Human, Mouse, Rat
Immunogen
Synthesized peptide derived from the Internal region of human Apaf-1
Clonality
Polyclonal
Tag
Apoptotic protease-activating factor 1
Applications
WB, IHC, IF, ELISA
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Molecular Weight
135kD
Precautions
The product listed herein is for research use only and is not intended for use in human or clinical diagnosis. Suggested applications of our products are not recommendations to use our products in violation of any patent or as a license. We cannot be responsible for patent infringements or other violations that may occur with the use of this product.
Shipping Conditions
Gel pack with blue ice.
Storage Conditions
Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.
Notes
Apaf-1 Polyclonal Antibody detects endogenous levels of Apaf-1 protein.
Formulation
Liquid solution
Buffer pH
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Applications Notes
Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000; IHC: 1:100-1:300; ELISA 1:20000; IF 1:50-200
Other Product Names
APAF1; KIAA0413; Apoptotic protease-activating factor 1; APAF-1
Tested Applications
WB, IHC, IF, IP, ELISA
Host or Source
Rabbit
Accession Number URL
http://www.uniprot.org/uniprot/O14727
Isotype
Rabbit IgG

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