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Apaf-1-ALT Polyclonal Antibody

CAT: 0965-JOT-AP00502-01Size: 20 µLDry Ice: NoHazardous: No
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CAT#:0965-JOT-AP00502-01Size:20 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
APAF1 encodes a cytoplasmic protein that initiates apoptosis. This protein (apoptotic peptidase activating factor 1) contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms.
CAS Number
9007-83-4
Synonyms
APAF1-interacting protein; APIP; APIP2; CGI-29 protein; MMRP19; dJ179L10.2; likely ortholog of mouse monocyte macrophage 19
Host
Rabbit
Reactivity
Human
Immunogen
The antiserum was produced against synthesized peptide derived from human APAF-1-ALT. AA range:289-338
Clonality
Polyclonal
Applications
WB, IHC-p, IF, ELISA
Stability
-20°C for one year
Concentration
1 mg/ml
Molecular Weight
40500
Antibody Type
Primary antibody
Isotype
IgG

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