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Apaf-1 Polyclonal Antibody

CAT: 0965-JOT-AP00501-01Size: 20 µLDry Ice: NoHazardous: No
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CAT#:0965-JOT-AP00501-01Size:20 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
APAF1 encodes a cytoplasmic protein that initiates apoptosis. Apoptotic protease-activating factor 1 contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms.
CAS Number
9007-83-4
Synonyms
APAF1; KIAA0413; Apoptotic protease-activating factor 1; APAF-1
Host
Rabbit
Reactivity
Human;Mouse;Rat
Immunogen
The antiserum was produced against synthesized peptide derived from the Internal region of human APAF1. AA range:501-550
Clonality
Polyclonal
Applications
WB, IHC-p, ELISA
Stability
-20°C for one year
Concentration
1 mg/ml
Molecular Weight
141840
Antibody Type
Primary antibody
Isotype
IgG