MerTK/Axl-IN-1

MerTK/Axl-IN-1

• CAS Number: 3036009-40-9
• UNSPSC Description: MerTK/Axl-IN-1 (Compound A-910) is a potent and selective dual MerTK/Axl inhibitor, with IC50s of 4.2 and 8.8 nM in Ba/F3, and 0.2 and 0.9 nM in HTRF. MerTK/Axl-IN-1 results in pMerTK inhibition in vivo. MerTK/Axl-IN-1 has long half-life, high oral exposure and bioavailability[1].
• Target Antigen: TAM Receptor
• Type: Reference compound
• Related Pathways: Protein Tyrosine Kinase/RTK
• Field of Research: Cancer; Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/mertk-axl-in-1.html
• Smiles: FC1=NC=CC=C1C2=CC(C(N[C@H]3CCC[C@@H]3OCC4=CC=C(C5=CC(CCC[C@@H]6N7CCN(C[C@@H](CO)O)CC7)=C6C=C5)C=C4)=O)=C(N)N=C2
• Molecular Weight: 694.84
• References & Citations: [1]Yu Y, et al. Discovery of A-910, a Highly Potent and Orally Bioavailable Dual MerTK/Axl-Selective Tyrosine Kinase Inhibitor. J Med Chem. 2024 Sep 16.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported